TY - JOUR T1 - Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse. JF - Elife Y1 - 2019 A1 - Zhang, Jie A1 - Li, Liang A1 - Huang, Haoliang A1 - Fang, Fang A1 - Webber, Hannah C A1 - Zhuang, Pei A1 - Liu, Liang A1 - Dalal, Roopa A1 - Tang, Peter H A1 - Mahajan, Vinit B A1 - Sun, Yang A1 - Li, Shaohua A1 - Zhang, Mingchang A1 - Goldberg, Jeffrey L A1 - Hu, Yang AB -

Understanding the molecular mechanism of glaucoma and development of neuroprotectants is significantly hindered by the lack of a reliable animal model that accurately recapitulates human glaucoma. Here, we sought to develop a mouse model for the secondary glaucoma that is often observed in humans after silicone oil (SO) blocks the pupil or migrates into the anterior chamber following vitreoretinal surgery. We observed significant intraocular pressure (IOP) elevation after intracameral injection of SO, and that SO removal allows IOP to return quickly to normal. This simple, inducible and reversible mouse ocular hypertension model shows dynamic changes of visual function that correlate with progressive retinal ganglion cell (RGC) loss and axon degeneration. It may be applicable with only minor modifications to a range of animal species in which it will generate stable, robust IOP elevation and significant neurodegeneration that will facilitate selection of neuroprotectants and investigating the pathogenesis of ocular hypertension-induced glaucoma.

VL - 8 U1 - https://www.ncbi.nlm.nih.gov/pubmed/31090540?dopt=Abstract ER -