TY - JOUR T1 - REPRODUCTIVE OPHTHALMOLOGY: The Intersection of Inherited Eye Diseases and Reproductive Technologies. JF - Retina Y1 - 2022 A1 - Park, Jong G A1 - Xu, Christine L A1 - Boyd, Allison A1 - Aghajanova, Lusine A1 - Mahajan, Vinit B A1 - Wood, Edward H KW - Child KW - Eye Diseases, Hereditary KW - Female KW - Fertilization in Vitro KW - Humans KW - Ophthalmology KW - Pregnancy KW - Preimplantation Diagnosis KW - Retrospective Studies AB -

PURPOSE: To propose a working framework for patients with inherited eye diseases presenting to ophthalmologists who are interested in assisted reproductive technology and preimplantation genetic testing.

METHODS: Retrospective chart review and case series of three families with inherited eye diseases who successfully underwent preimplantation genetic testing, in vitro fertilization, and birth of unaffected children.

RESULTS: Preimplantation genetic testing was performed for three families with different inherited eye diseases, which included autosomal dominant retinitis pigmentosa, autosomal recessive achromatopsia, and X-linked Goltz syndrome. Preimplantation genetic testing led to the identification of unaffected embryos, which were then selected for in vitro fertilization and resulted in the birth of unaffected children.

CONCLUSION: A close collaboration between patients, families, ophthalmologists, reproductive genetic counselors, and reproductive endocrinology and infertility specialists is the ideal model for taking care of patients interested in preimplantation genetic testing for preventing the transmission of inherited eye diseases.

VL - 42 IS - 11 ER - TY - JOUR T1 - Intravitreal Anti-VEGF Injections in Pregnancy: Case Series and Review of Literature. JF - J Ocul Pharmacol Ther Y1 - 2015 A1 - Polizzi, Silvio A1 - Mahajan, Vinit B KW - Adult KW - Angiogenesis Inhibitors KW - Bevacizumab KW - Female KW - Humans KW - Infant, Newborn KW - Intravitreal Injections KW - Pregnancy KW - Pregnancy Complications KW - Pregnancy Outcome KW - Risk Factors KW - Vascular Endothelial Growth Factor A AB -

The use of intravitreal antivascular endothelial growth factor (anti-VEGF) injection is gaining wide acceptance as an off-label therapy for diseases that may affect pregnant women. However, these drugs may cause systemic side effects in the mother and fetal harm. This could lead specialists to not administer the drug or women to abort the fetus or to refuse treatment during pregnancy. We report the course of pregnancy in 3 women treated with intravitreal bevacizumab and provide a review of the literature on the use of intravitreal anti-VEGF in pregnancy. Our patients did not have any drug-related adverse event and delivered healthy full-term infants, although one of the women had risk factors for miscarriage. Infants reached all developmental milestones appropriately during infancy. A literature search on the use of intravitreal anti-VEGF injection in pregnancy was undertaken. Data for this review were identified by searches of PubMed and references from relevant articles using the search terms "pegaptanib," "bevacizumab," "ranibizumab," "aflibercept," "anti-VEGF," "intravitreal injection," "pregnant," "pregnancy," "abortion," "miscarriage," "preeclampsia," "embryo-fetal toxicity," "fetal malformations," "teratogenesis," "adverse events," and "maternofetal complications" in multiple combinations. We believe that intravitreal anti-VEGF can be given during pregnancy only when potential benefit to the woman justifies the potential risks to the fetus. When making a decision about whether to give drugs during pregnancy, it is important to consider the timing of exposure and its relationship to windows of developmental sensitivity. We believe that this review will be useful to specialists to inform and possibly treat their pregnant patients.

VL - 31 IS - 10 U1 - http://www.ncbi.nlm.nih.gov/pubmed/26302032?dopt=Abstract ER - TY - JOUR T1 - Intravitreal bevacizumab during pregnancy. JF - Retina (Philadelphia, Pa.) Y1 - 2010 A1 - Tarantola, Ryan M A1 - Folk, James C A1 - Boldt, H Culver A1 - Mahajan, Vinit B KW - Adult KW - Angiogenesis Inhibitors KW - Antibodies, Monoclonal KW - Choroidal Neovascularization KW - Eye Infections, Fungal KW - Female KW - Follow-Up Studies KW - Gestational Age KW - Histoplasmosis KW - Humans KW - Intravitreal Injections KW - Off-Label Use KW - Pregnancy KW - Pregnancy Complications KW - Sarcoidosis KW - Tomography, Optical Coherence KW - Uveitis KW - Vascular Endothelial Growth Factor A KW - Visual Acuity AB -

To report the clinical course of four women treated with intravitreal bevacizumab during pregnancy.

VL - 30 IS - 9 U1 - http://www.ncbi.nlm.nih.gov/pubmed/20924262?dopt=Abstract ER -