|Title||Insights into Retinal Development Using Live Imaging in Female Carriers of Choroideremia.|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Wert, Katherine J., Bakall Benjamin, Bassuk Alexander G., Tsang Stephen H., and Mahajan Vinit B.|
|Journal||Ophthalmic Surg Lasers Imaging Retina|
|Date Published||2019 May 01|
Lineage tracing can provide key insights into the development of tissues, such as the retina. Yet it is not possible to manipulate human cells during embryogenesis. The authors observed a distinct phenotype in female carriers of X-linked disorders, in particular, carriers of choroideremia caused by mutations in CHM, encoding Rab escort protein-1. The authors found that X chromosome inactivation provides a method for retinal lineage tracing in human patients. Live imaging of female carriers displays a developmental pattern that is different within the peripheral retina compared with the posterior retina and provides important insights into the development and migration of retinal cells. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:e158-e162.].
|Alternate Journal||Ophthalmic Surg Lasers Imaging Retina|