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Proteomics Lab

Proteomics is the culmination of advances in chemistry, physics, bioinformatics, and molecular biology that allow the study of thousands of proteins simultaneously. A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest. This strategy is especially important in eye diseases where there are limited cell and animal models.

We are using proteomics to discover biomarkers, therapeutic targets, and molecular pathways involved in several eye diseases where diagnosis is difficult and current treatment is inadequate.

Projects

A multi-institution precision health consortium for collecting ophthalmic surgical samples.

We are using proteomics to study the vitreous fluid from eyes with ADNIV.

A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest.

The vitreous is an optically clear, collagenous extracellular matrix that fills the inside of the eye and overlies the retina.

News

Nov 7 2023 | Posted In: Press
Palo Alto, CA — Research from the Mahajan lab was featured in NIH's newsite, NIH Research Matters.
Oct 19 2023 | Posted In: 20/20 Blog
  Palo Alto, CA — The eyes may be a window into the soul, but Stanford research scientists are now showing the eyes may also be a window into overall human health. 
Oct 19 2023 | Posted In: 20/20 Blog
Palo Alto, CA — Using AI programming, Mahajan Lab member Julian Wolf, M.D., M.S., an expert in big data analytics, predicted the global and cellular molecular age of diseased eyes using high resolution proteomics of human eye fluid from living patients.
Oct 19 2023 | Posted In: 20/20 Blog
Palo Alto, CA —By integrating microvolume liquid biopsy proteomics, single-cell transcriptomics and artificial intelligence, the Mahajan research team created a powerful tool to examine disease mechanisms at the cell level in living humans.
Oct 1 2022 | Posted In: 20/20 Blog
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Publications

Liquid-biopsy proteomics combined with AI identifies cellular drivers of eye aging and disease in vivo., Wolf, Julian, Rasmussen Ditte K., Sun Young Joo, Vu Jennifer T., Wang Elena, Espinosa Camilo, Bigini Fabio, Chang Robert T., Montague Artis A., Tang Peter H., et al. , Cell, 2023 Oct 26, Volume 186, Issue 22, p.4868-4884.e12, (2023)
Investigation of Cas9 antibodies in the human eye., Toral, Marcus A., Charlesworth Carsten T., Ng Benjamin, Chemudupati Teja, Homma Shota, Nakauchi Hiromitsu, Bassuk Alexander G., Porteus Matthew H., and Mahajan Vinit B. , Nat Commun, 2022 02 25, Volume 13, Issue 1, p.1053, (2022)
Proteomic analysis of autoimmune retinopathy implicates NrCAM as a potential biomarker., Al-Moujahed, Ahmad, Velez Gabriel, Vu Jennifer T., de Carvalho Jose R. Lima, Levi Sarah R., Bassuk Alexander G., Sepah Yasir J., Tsang Stephen H., and Mahajan Vinit B. , Ophthalmol Sci, 2022 Jun, Volume 2, Issue 2, (2022)
Calpains as mechanistic drivers and therapeutic targets for ocular disease., Vu, Jennifer T., Wang Elena, Wu Jolan, Sun Young Joo, Velez Gabriel, Bassuk Alexander G., Lee Soo Hyeon, and Mahajan Vinit B. , Trends Mol Med, 2022 08, Volume 28, Issue 8, p.644-661, (2022)
Author Correction: Investigation of Cas9 antibodies in the human eye., Toral, Marcus A., Charlesworth Carsten T., Ng Benjamin, Chemudupati Teja, Homma Shota, Nakauchi Hiromitsu, Bassuk Alexander G., Porteus Matthew H., and Mahajan Vinit B. , Nat Commun, 2022 Apr 12, Volume 13, Issue 1, p.2109, (2022)
Molecular Characterization of a Rare Case of Bilateral Vitreoretinal T Cell Lymphoma through Vitreous Liquid Biopsy., Cani, Andi K., Toral Marcus A., Balikov Daniel A., Betz Bryan L., Hu Kevin, Liu Chia-Jen, Prifti Matthew V., Chinnaiyan Arul M., Tomlins Scott A., Mahajan Vinit B., et al. , Int J Mol Sci, 2021 Jun 05, Volume 22, Issue 11, (2021)
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