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Proteomics Lab

Proteomics is the culmination of advances in chemistry, physics, bioinformatics, and molecular biology that allow the study of thousands of proteins simultaneously. A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest. This strategy is especially important in eye diseases where there are limited cell and animal models.

We are using proteomics to discover biomarkers, therapeutic targets, and molecular pathways involved in several eye diseases where diagnosis is difficult and current treatment is inadequate.

Projects

A multi-institution precision health consortium for collecting ophthalmic surgical samples.

We are using proteomics to study the vitreous fluid from eyes with ADNIV.

A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest.

The vitreous is an optically clear, collagenous extracellular matrix that fills the inside of the eye and overlies the retina.

News

Jun 8 2020 | Posted In: 20/20 Blog, Press
Palo Alto, Ca — Genetic testing doesn’t always provide a diagnosis, so Vinit Mahajan M.D., Ph.D., associate professor of ophthalmology at Stanford University, has applied proteomics to better understand disease in his patients. 
May 1 2020 | Posted In: 20/20 Blog
 
Apr 20 2020 | Posted In: 20/20 Blog
Palo Alto, CA — Is there something to feed retinal cells that can give them the energy to withstand gene mutations that make them sick?
Mar 31 2020 | Posted In: 20/20 Blog
Palo Alto, CA — On an international Zoom conference, Gabriel Velez, an M.D., Ph.D. student in the Mahajan Lab, successfully presented his Ph.D. thesis defense seminar. 
Sep 28 2019 | Posted In: 20/20 Blog
Portland, OR — Vinit Mahajan M.D., Ph.D., Vice Chair of Research for the Stanford Ophthalmology Department, traveled to Portland, Oregon to give the keynote lecture at the 10th Annual Gained in Translation Symposium held at the OHSU Knight Cancer Research Building.  

Publications

Proteomic analysis of intermediate uveitis suggests myeloid cell recruitment and implicates IL-23 as a therapeutic target., Sepah, Yasir J., Velez Gabriel, Tang Peter H., Yang Jing, Chemudupati Teja, Li Angela S., Nguyen Quan D., Bassuk Alexander G., and Mahajan Vinit B. , Am J Ophthalmol Case Rep, 2020 Jun, Volume 18, p.100646, (2020)
HTRA1, an age-related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1, Lin, Michael K., Yang Jin, Hsu Chun Wei, Gore Anuradha, Bassuk Alexander G., Brown Lewis M., Colligan Ryan, Sengillo Jess D., Mahajan Vinit B., and Tsang Stephen H. , Aging Cell, 05/2018, (2018)
Proteomic analysis of the human retina reveals region-specific susceptibilities to metabolic-and oxidative stress-related diseases, Velez, Gabriel, Machlab Daniel A., Tang Peter H., Sun Yang, Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , PloS one, Volume 13, p.e0193250, (2018)
Bevacizumab injection in patients with neovascular age-related macular degeneration increases angiogenic biomarkers, Cabral, Thiago, Lima Luiz H., Mello Luiz Guilherme, Polido Júlia, Correa Éverton P., Oshima Akiyoshi, Duong Jimmy, Serracarbassa Pedro, Regatieri Caio V., Mahajan Vinit B., et al. , Ophthalmology Retina, Volume 2, p.31–37, (2018)
Personalized Proteomics for Precision Health: Identifying Biomarkers of Vitreoretinal Disease., Velez, Gabriel, Tang Peter H., Cabral Thiago, Cho Galaxy Y., Machlab Daniel A., Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , Transl Vis Sci Technol, 2018 Sep, Volume 7, Issue 5, p.12, (2018)
Dissection of Human Retina and RPE-Choroid for Proteomic Analysis., Cabral, Thiago, Toral Marcus A., Velez Gabriel, DiCarlo James E., Gore Anuradha M., Mahajan M, Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , Journal of visualized experiments: JoVE, (2017)