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Proteomics Lab

Proteomics is the culmination of advances in chemistry, physics, bioinformatics, and molecular biology that allow the study of thousands of proteins simultaneously. A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest. This strategy is especially important in eye diseases where there are limited cell and animal models.

We are using proteomics to discover biomarkers, therapeutic targets, and molecular pathways involved in several eye diseases where diagnosis is difficult and current treatment is inadequate.

Projects

A multi-institution precision health consortium for collecting ophthalmic surgical samples.

We are using proteomics to study the vitreous fluid from eyes with ADNIV.

A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest.

The vitreous is an optically clear, collagenous extracellular matrix that fills the inside of the eye and overlies the retina.

News

Oct 1 2022 | Posted In: 20/20 Blog
Sep 27 2022 | Posted In: 20/20 Blog
San Francisco, CA —Mahajan lab postdoctoral fellows Young Joo Sun Ph.D. and David Dennis Ph.D. attended the inaugural Chemical Biology Symposium hosted by UCSF’s Quantitative Biosciences Institute, which had been delayed by COVID.
Aug 9 2022 | Posted In: 20/20 Blog
 
Jul 8 2022 | Posted In: 20/20 Blog
Jun 21 2022 | Posted In: 20/20 Blog
San Francisco, CA – The Federation of Clinical Immunology Societies (FOCiS) was founded in 2001 by Stanford University professor C.

Publications

Calpains as mechanistic drivers and therapeutic targets for ocular disease., Vu, Jennifer T., Wang Elena, Wu Jolan, Sun Young Joo, Velez Gabriel, Bassuk Alexander G., Lee Soo Hyeon, and Mahajan Vinit B. , Trends Mol Med, 2022 08, Volume 28, Issue 8, p.644-661, (2022)
Author Correction: Investigation of Cas9 antibodies in the human eye., Toral, Marcus A., Charlesworth Carsten T., Ng Benjamin, Chemudupati Teja, Homma Shota, Nakauchi Hiromitsu, Bassuk Alexander G., Porteus Matthew H., and Mahajan Vinit B. , Nat Commun, 2022 Apr 12, Volume 13, Issue 1, p.2109, (2022)
Investigation of Cas9 antibodies in the human eye., Toral, Marcus A., Charlesworth Carsten T., Ng Benjamin, Chemudupati Teja, Homma Shota, Nakauchi Hiromitsu, Bassuk Alexander G., Porteus Matthew H., and Mahajan Vinit B. , Nat Commun, 2022 02 25, Volume 13, Issue 1, p.1053, (2022)
Proteomic analysis of autoimmune retinopathy implicates NrCAM as a potential biomarker., Al-Moujahed, Ahmad, Velez Gabriel, Vu Jennifer T., de Carvalho Jose R. Lima, Levi Sarah R., Bassuk Alexander G., Sepah Yasir J., Tsang Stephen H., and Mahajan Vinit B. , Ophthalmol Sci, 2022 Jun, Volume 2, Issue 2, (2022)
Structure-based phylogeny identifies Avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice., Sun, Young Joo, Velez Gabriel, Parsons Dylan E., Li Kun, Ortiz Miguel E., Sharma Shaunik, McCray Paul B., Bassuk Alexander G., and Mahajan Vinit B. , J Clin Invest, 2021 Apr 12, (2021)
Peptidomimetics Therapeutics for Retinal Disease., Parsons, Dylan E., Lee Soo Hyeon, Sun Young Joo, Velez Gabriel, Bassuk Alexander G., Smith Mark, and Mahajan Vinit B. , Biomolecules, 2021 Feb 24, Volume 11, Issue 3, (2021)