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Proteomics Lab

Proteomics is the culmination of advances in chemistry, physics, bioinformatics, and molecular biology that allow the study of thousands of proteins simultaneously. A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest. This strategy is especially important in eye diseases where there are limited cell and animal models.

We are using proteomics to discover biomarkers, therapeutic targets, and molecular pathways involved in several eye diseases where diagnosis is difficult and current treatment is inadequate.

Projects

A multi-institution precision health consortium for collecting ophthalmic surgical samples.

We are using proteomics to study the vitreous fluid from eyes with ADNIV.

A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest.

The vitreous is an optically clear, collagenous extracellular matrix that fills the inside of the eye and overlies the retina.

News

Sep 5 2019 | Posted In: 20/20 Blog, Press
Palo Alto, CA – The Stanford Ophthalmology Department highlighted its impressive clinical, surgical, and research achievements in its first annual report
Aug 13 2019 | Posted In: 20/20 Blog
Palo Alto, CA – An Ocular Melanoma Proteomics Symposium at Stanford University was hosted by Vinit Mahajan M.D., Ph.D., Vice Chair of Research in Ophthalmology, and Prithvi Mruthyun
Jul 19 2019 | Posted In: 20/20 Blog
Pacific Grove, CA – Every three years The Biology of Calpains in Health and Disease Conference brings together an international, multidisciplinary group of researchers who are examining the role calpains play in diseases like re
Jul 8 2019 | Posted In: 20/20 Blog
Palo Alto, CA – Vinit Mahajan M.D., Ph.D., Stanford vitreoretinal surgeon and Vice Chair of Research in the department of ophthalmology, gave an overview on molecular therapies at the 2019 Stanford’s Bay Area Ophthalmology Course
Jun 19 2019 | Posted In: 20/20 Blog, Press
Palo Alto, CA - Vinit Mahajan M.D., Ph.D., Stanford vitreoretinal surgeon and Vice Chair of Research in the department of ophthalmology, was recently featured in the article, “

Publications

Personalized Proteomics for Precision Health: Identifying Biomarkers of Vitreoretinal Disease., Velez, Gabriel, Tang Peter H., Cabral Thiago, Cho Galaxy Y., Machlab Daniel A., Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , Transl Vis Sci Technol, 2018 Sep, Volume 7, Issue 5, p.12, (2018)
HTRA1, an age-related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1, Lin, Michael K., Yang Jin, Hsu Chun Wei, Gore Anuradha, Bassuk Alexander G., Brown Lewis M., Colligan Ryan, Sengillo Jess D., Mahajan Vinit B., and Tsang Stephen H. , Aging Cell, 05/2018, (2018)
Proteomic analysis of the human retina reveals region-specific susceptibilities to metabolic-and oxidative stress-related diseases, Velez, Gabriel, Machlab Daniel A., Tang Peter H., Sun Yang, Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , PloS one, Volume 13, p.e0193250, (2018)
Bevacizumab injection in patients with neovascular age-related macular degeneration increases angiogenic biomarkers, Cabral, Thiago, Lima Luiz H., Mello Luiz Guilherme, Polido Júlia, Correa Éverton P., Oshima Akiyoshi, Duong Jimmy, Serracarbassa Pedro, Regatieri Caio V., Mahajan Vinit B., et al. , Ophthalmology Retina, Volume 2, p.31–37, (2018)
Proteomic analysis of elevated intraocular pressure with retinal detachment, Velez, Gabriel, C Roybal Nathaniel, Binkley Elaine, Bassuk Alexander G., Tsang Stephen H., and Mahajan Vinit B. , American journal of ophthalmology case reports, Volume 5, p.107–110, (2017)
Therapeutic drug repositioning using personalized proteomics of liquid biopsies, Velez, Gabriel, Bassuk Alexander G., Colgan Diana, Tsang Stephen H., and Mahajan Vinit B. , JCI insight, Volume 2, (2017)