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Human Microsurgery

We use evidence-based approaches to study and improve surgery for our patients. Once surgeons and scientists have a molecular target in their sights, numerous molecular drugs are available to them. These may involve enzymes, genes, antibodies, or chemicals. Eye surgeons can precisely and safely deliver any of these molecules near specific cells in the eye, avoiding the toxicity and issues associated with drugs taken by mouth or injected into the blood stream. Once delivered, patients can be observed noninvasively in the clinic using ultra-high-resolution cameras.

Projects

A multi-institution precision health consortium for collecting ophthalmic surgical samples.

We conducted laboratory and clinical studies on macular hole repair.

We conduct studies to develop safer, more efficient surgery in patients.

Evidence-based approaches for new surgical treatments and research to discover the molecular causes.

News

Oct 16 2019 | Posted In: 20/20 Blog
Palo Alto, CA — A gene therapy clinical trial for Dry Age Related Macular Degeneration (AMD) is beginning at the Byers Eye Institute under the direction of Vinit Mahajan M.D., Ph.D., associate professor and Vice Chair for Research in Ophthalm
Oct 14 2019 | Posted In: 20/20 Blog
Palo Alto, CA – Dry macular degeneration is a common eye condition that usually occurs in people over 50. It is characterized by blurring of the central vision along with a decreased ability to see colors and fine details.
Aug 9 2019 | Posted In: 20/20 Blog
Palo Alto, CA – As the eye ages, vision problems increase, making it harder to do everyday activities. When an older patient comes in with blurred or distorted central vision, one of the causes an ophthalmologist will check for is a macular hole.
Jun 4 2019
Palo Alto, CA – Calling a disease orphan, or rare, can be misleading considering millions of Americans suffer from thousands of orphan diseases that are often serious or life threatening.
Jun 4 2019 | Posted In: 20/20 Blog
Palo Alto, CA – Calling a disease orphan, or rare, can be misleading considering millions of Americans suffer from thousands of orphan diseases that are often serious or life threatening.

Publications

Autologous stem cell therapy for inherited and acquired retinal disease, Apatoff, Mary Ben L., Sengillo Jesse D., White Eugenia C., Bakhoum Mathieu F., Bassuk Alexander G., Mahajan Vinit B., and Tsang Stephen H. , Regenerative medicine, (2018)
Personalized Proteomics for Precision Health: Identifying Biomarkers of Vitreoretinal Disease., Velez, Gabriel, Tang Peter H., Cabral Thiago, Cho Galaxy Y., Machlab Daniel A., Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , Transl Vis Sci Technol, 2018 Sep, Volume 7, Issue 5, p.12, (2018)
Quantitative progression of retinitis pigmentosa by optical coherence tomography angiography, Jauregui, Ruben, Park Karen Sophia, Duong Jimmy K., Mahajan Vinit B., and Tsang Stephen H. , Scientific reports, Volume 8, p.13130, (2018)
Limbal Trocar-Cannulas for Complex Vitrectomy Surgery., Mears, Katrina A., and Mahajan Vinit B. , Retina, 2017 Jul 21, (2017)
Dissection of Human Retina and RPE-Choroid for Proteomic Analysis., Cabral, Thiago, Toral Marcus A., Velez Gabriel, DiCarlo James E., Gore Anuradha M., Mahajan M, Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , Journal of visualized experiments: JoVE, (2017)
Comparison of microbiology and visual outcomes of patients undergoing small-gauge and 20-gauge vitrectomy for endophthalmitis., Almeida, David R. P., Chin Eric K., Shah Shaival S., Bakall Benjamin, Gehrs Karen M., H Boldt Culver, Russell Stephen R., Folk James C., and Mahajan Vinit B. , Clin Ophthalmol, 2016, Volume 10, p.167-72, (2016)