The mouse eye is an important genetic model for the translational study of human ophthalmic disease. Blinding diseases in humans, such as macular degeneration, photoreceptor degeneration, cataract, glaucoma, retinoblastoma, and diabetic retinopathy can be recapitulated in transgenic mice. Our team has extensive microsurgical experience with eyes, and we develop and share surgical methods for preclinical research that tests therapies we hope will eventually be used for humans. All studies are conducted in accordance with the ARVO Statement for Use of Animals in Ophthalmic and Vision Research.