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2026

Gene therapy for Bietti crystalline corneoretinal dystrophy: a phase 1/2 clinical trial   |   Yang L, Xing D, Zhang J, Liu B, Jiang X, Chen S, Li W, Qu B, Qiao J, Feng X, Jia H, Hu X, Yu S, Jia R, Wang L, Mahajan VB, Dou H, Lu F, Li X   |   Mol Ther   |   Details
Implantable ocular therapeutic systems: an insight into their clinical potential in the long-term treatment of ocular diseases   |   Kim H, Kang NW, Hong W, Abdollahramezani S, Ngo GH, Raja D, Peters O, Mahajan VB, Myung D, DeBoer C   |   Biofabrication   |   Details
Oculomics and AI: The eye as a biomarker for health span   |   Le Yi Wong J, Cheng H, Peh WJ, Ho D, Wong TY, Hui CYY, Ting DSJ, Bee YM, Goh SY, Apte RS, Mahajan VB, Goldberg JL, Bischof E, Sinclair DA, Cheung CC, Chan HH, Fukutsu K, Tan TF, Quek CWN, Hong ASY, Jin LY, Wagner SK, Keane P, Ferrara D, Eydelman M, Lam DSC, Wang X, Ting DSW   |   Asia Pac J Ophthalmol   |   Details
The Final Millimeter: A Single-Center Retrospective Analysis of an Integrated Pneumatic Microinjection System for Subretinal Gene Therapy   |   Almeida DRP, Mahajan VB   |   Clin Ophthalmol   |   Details
Oculomics and AI: The eye as a biomarker for health span   |   Wong JLY, Cheng H, Peh WJ, Ho D, Wong TY, Hui CYY, Ting DSJ, Bee YM, Goh SY, Apte RS, Mahajan VB, Goldberg JL, Bischof E, Sinclair DA, Cheung CY, Chan HH, Fukutsu K, Tan TF, Quek CWN, Hong ASY, Jin LY, Wagner SK, Keane PA, Ferrara D, Eydelman M, Lam DSC, Wang X, Ting DSW   |   Asia Pac J Ophthalmol   |   Details
A Simplified Classification for Age-Related Macular Degeneration Based on Optical Coherence Tomography   |   Yeh TC, Lin JB, Mruthyunjaya P, Leng T, DeBoer C, Sepah YJ, Almeida DRP, Smith S, Mahajan VB   |   Ophthalmic Surg Lasers Imaging Retina   |   Details
Mitochondrial Transplantation in the Eye: A Review and Evaluation of Surgical Approaches   |   Cakir B, Yeh TC, Lin CH, Wu MR, Boilard É, Pelletier M, Singh AM, Breton Y, Patel S, Benson T, Almeida DR, Wang S, Mahajan VB   |   bioRxiv   |   Details
Safety and Efficacy of Vitreoretinal Office-Based Surgery: A Case Series of 173 Procedures in an Office-Based Suite   |   Mahajan VB, Kadmiel M, Almeida DRP   |   Epub   |   Details
A novel IDS variant associated with an isolated ocular phenotype in Hunter syndrome   |   Yeh TC, Velez G, Lee SH, Ngo GH, Kumar A, Al-Moujahed A, Yu C, Leung LS, Mruthyunjaya P, Mahajan VB   |   Details
Preoperative Classification of Submembrane Spaces for Optical Coherence Tomography-Guided Epiretinal Membranectomy   |   Almeida DRP, Chin EK, Mahajan VB   |   Details
Multimodal AI fuses proteomic and EHR data for rational prioritization of protein biomarkers in diabetic retinopathy   |   Lin JB, Mataraso SJ, Chadha M, Velez G, Mruthyunjaya P, Aghaeepour N, Mahajan VB   |   Details
Epidemiology of Inherited Retinal Diseases in the United States: IRIS® Registry (Intelligent Research in Sight) Analysis   |   Al-Moujahed A, Haque ME, Mahajan VB, Huckfeldt R, Pershing S   |   Ophthalmic Surg Lasers Imaging Retina   |   Details
Multi-omics liquid biopsy identifies mitochondrial dysfunction in geographic atrophy and supports the longevity-associated metabolite α-ketoglutarate as a therapeutic strategy   |   Yeh TC, Velez G, Prasad A, Lee SH, Rasmussen DK, Kumar A, Chadha M, Dabaja MZ, Singh AM, Sanislo S, Smith S, Mryuthyunjaya P, Montague A, Bassuk AG, Almeida D, Dufour A, Mahajan VB   |   medRxiv   |   Details

2025

Gestational hypertension increases risk of seizures in children and mice   |   Baojian Xue, Serena B Gumusoglu, Grant Tiarks, Brittany P Todd, Angela Wong, Donna A Santillan, Chin-Chi Kuo, Hsiu-Yin Chiang, Rohith Ravindranath, Sophia Y Wang, Vinit B Mahajan, Alan Kim Johnson, Heath A Davis, Polly Ferguson, Elizabeth A Newell, Mark K Santillan, Jason M Misurac, Alexander G Bassuk   |   J Clin Invest   |   Details
Discovery of a selective alpha-kinase 1 inhibitor for the rare genetic disease ROSAH syndrome   |   Jieqing Fan, Danyang Liu, Zhu Ming, Chunyu Yan, Huaixin Dang, Yanfang Pan, Xiong Wei, Zhengle Zhao, Wenzhi Wang, Shuai Zhang, Linlin Chen, Shuo Cai, Jiangbin Ke, Yaru Luo, Linjie Rao, Jingjing Chen, Zhenjie Chen, Junlin Zhou, Feixiang Chen, Xiaodi Duan, Boyue Ren, Tong-Ruei R Li, Lawrence Melvin, Jeysen Yogaratnam, Vinit B Mahajan, Hongmei Song, Henri Lichenstein, Tian Xu, Cong Xu   |   Nat Commun   |   Details
Near-Real Surgical Specimens (NRSS): A Novel Platform for Standardized Assessment of Suprachoroidal Drug Delivery   |   Vinit B Mahajan, Yoreh Barak, David R P Almeida   |   Transl Vis Sci Technol   |   Details
Safety and efficacy of MCO-010 optogenetic therapy in patients with Stargardt disease in USA (STARLIGHT): an open-label multi-center Ph2 trial   |   Byron L Lam, Vitaliy Zak Victor H Gonzalez, Ninel Z Gregori, Sai H Chavala, Subrata Batabyal, Michael Carlson, Sanghoon Kim, Ananta Ayyagari, Jean Chang, Hayley Lane, Nozhat Choudry, John Koester, Mark Von Tress, Jody Piltz-Seymour, Najam A Sharif, Stephen H Tsang, Vinit B Mahajan, David S Boyer, Allen C Ho, Samuel B Barone, Samarendra K Mohanty   |   EClinicalMedicine   |   Details
Elevated PRDM13 Disrupts Photoreceptor Function and Survival in the Mammalian Retina   |   Emily R Nettesheim, Ashley A Rowe, Tiffany Yee, Ahmed Alshaikhsalama, Tyler Cepica, Vijaya Dutt, Samita S Virani, Glen Wickersham, Vinit B Mahajan, Kent W Small, Katherine J Wert   |   Invest Ophthalmol Vis Sci   |   Details
3D Bioprinting of Cellular Therapeutic Systems in Ophthalmology: from Bioengineered Tissue to Personalized Drug Delivery   |   Hyeonji Kim, Gia-Han Ngo, Wen Hong, Soo Hyeon Lee, Vinit B Mahajan, Charles DeBoer   |   Curr Ophthalmol Rep   |   Details
Ophthalmic drug discovery and development using artificial intelligence and digital health technologies   |   Haoran Cheng, Joy Le Yi Wong, Chrystie Wan Ning Quek, Jeffrey L Goldberg, Vinit B Mahajan, Tien Yin Wong, Jodhbir S Mehta, Daniel S W Ting, Darren S J Ting   |   NPJ Digit Med   |   Details

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