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2026

Gene therapy for Bietti crystalline corneoretinal dystrophy: a phase 1/2 clinical trial   |   Yang L, Xing D, Zhang J, Liu B, Jiang X, Chen S, Li W, Qu B, Qiao J, Feng X, Jia H, Hu X, Yu S, Jia R, Wang L, Mahajan VB, Dou H, Lu F, Li X   |   Mol Ther   |   Details

2025

In-clinic vitreous biopsy peel pack technique   |   Charles DeBoer, Cindy Zhao, Prithvi Mruthyunjaya, Vinit B Mahajan, Karen M Wai, Steven R Sanislo   |   International Journal Retina Vitreous   |   Details
A synthetic opsin restores vision in patients with severe retinal degeneration   |   Samarendra K Mohanty, Santosh Mahapatra, Subrata Batabyal, Michael Carlson, Gayatri Kanungo, Ananta Ayyagari, Kissaou Tchedre, Joel A Franco, Michael Singer, Samuel B Barone, Sai Chavala, Vinit B Mahajan   |   Mol Ther .   |   Details
Enhanced genotype-phenotype analysis using multimodal adaptive optics and 3D protein structure in Bietti Crystalline Dystrophy   |   Aarushi Kumar, Young Joo Sun, Ditte K Rasmussen, Aubrey Hargrave, Claudia Phillips, Jennifer T Vu, Mauricio G S Costa, Loh-Shan B Leung, Charles Yu, Alfredo Dubra, Vinit B Mahajan   |   Am J Ophthalmol Case Rep.   |   Details
Artificial intelligence's contribution to biomedical literature search: revolutionizing or complicating?   |   Rui Yip, Young Joo Sun, Alexander G Bassuk, Vinit B Mahajan   |   PLOS Digit Health   |   Details
Response: Promise and open questions of optogenetic vision restoration by MCO   |   Samarendra K Mohanty, Santosh Mahapatra, Subrata Batabyal, Michael Carlson, Gayatri Kanungo, Ananta Ayyagari, Kissaou Tchedre, Joel A Franco, Michael Singer, Samuel Barone, Sai Chavala, Vinit B Mahajan   |   Molecular Therapy   |   Details
N-terminomics and proteomics analysis of Calpain-2 reveal key proteolytic processing of metabolic and cell adhesion proteins   |   Anjali Kapilan, Mitchell Bulluss, Alexander R Ziegler, Mohamed Dabaja, Afshin Derakhshani, Anthonia Anowai, Victoria Armstrong, Rhiannon Campden, Daniel Young, Young Joo Sun, Nichollas E Scott, Laura E Edgington-Mitchell, Vinit B Mahajan, Antoine Dufour   |   Protein Science   |   Details
Unravelling CYP4V2: Clinical features, genetic insights, pathogenic mechanisms and therapeutic strategies in Bietti crystalline corneoretinal dystrophy   |   Ruixuan Jia, Shaohong Chen, Wang Li, Jinlu Zhang, Baoyuan Qu, Jing Qiao, Xiang Meng, Shicheng Yu, Xiaozhen Liu, Boling Xu, Tianjin Chen, Xiuping Shen, Wenmin Sun, Hongliang Dou, Vinit B Mahajan, Qiongjiong Zhang, Liping Yang   |   Prog Retin Eye Res   |   Details
Structure-function analysis of CNGA3-associated achromatopsia patient variants complements clinical genomics in pathogenicity determination   |   Ditte K Rasmussen, Young Joo Sun, Joel A Franco, Aarushi Kumar, Jennifer T Vu, Alexander G Bassuk, Vinit B Mahajan   |   Orphanet J Rare Dis   |   Details
Gestational hypertension increases risk of seizures in children and mice   |   Baojian Xue, Serena B Gumusoglu, Grant Tiarks, Brittany P Todd, Angela Wong, Donna A Santillan, Chin-Chi Kuo, Hsiu-Yin Chiang, Rohith Ravindranath, Sophia Y Wang, Vinit B Mahajan, Alan Kim Johnson, Heath A Davis, Polly Ferguson, Elizabeth A Newell, Mark K Santillan, Jason M Misurac, Alexander G Bassuk   |   J Clin Invest   |   Details
Discovery of a selective alpha-kinase 1 inhibitor for the rare genetic disease ROSAH syndrome   |   Jieqing Fan, Danyang Liu, Zhu Ming, Chunyu Yan, Huaixin Dang, Yanfang Pan, Xiong Wei, Zhengle Zhao, Wenzhi Wang, Shuai Zhang, Linlin Chen, Shuo Cai, Jiangbin Ke, Yaru Luo, Linjie Rao, Jingjing Chen, Zhenjie Chen, Junlin Zhou, Feixiang Chen, Xiaodi Duan, Boyue Ren, Tong-Ruei R Li, Lawrence Melvin, Jeysen Yogaratnam, Vinit B Mahajan, Hongmei Song, Henri Lichenstein, Tian Xu, Cong Xu   |   Nat Commun   |   Details
Near-Real Surgical Specimens (NRSS): A Novel Platform for Standardized Assessment of Suprachoroidal Drug Delivery   |   Vinit B Mahajan, Yoreh Barak, David R P Almeida   |   Transl Vis Sci Technol   |   Details
Safety and efficacy of MCO-010 optogenetic therapy in patients with Stargardt disease in USA (STARLIGHT): an open-label multi-center Ph2 trial   |   Byron L Lam, Vitaliy Zak Victor H Gonzalez, Ninel Z Gregori, Sai H Chavala, Subrata Batabyal, Michael Carlson, Sanghoon Kim, Ananta Ayyagari, Jean Chang, Hayley Lane, Nozhat Choudry, John Koester, Mark Von Tress, Jody Piltz-Seymour, Najam A Sharif, Stephen H Tsang, Vinit B Mahajan, David S Boyer, Allen C Ho, Samuel B Barone, Samarendra K Mohanty   |   EClinicalMedicine   |   Details
Elevated PRDM13 Disrupts Photoreceptor Function and Survival in the Mammalian Retina   |   Emily R Nettesheim, Ashley A Rowe, Tiffany Yee, Ahmed Alshaikhsalama, Tyler Cepica, Vijaya Dutt, Samita S Virani, Glen Wickersham, Vinit B Mahajan, Kent W Small, Katherine J Wert   |   Invest Ophthalmol Vis Sci   |   Details
3D Bioprinting of Cellular Therapeutic Systems in Ophthalmology: from Bioengineered Tissue to Personalized Drug Delivery   |   Hyeonji Kim, Gia-Han Ngo, Wen Hong, Soo Hyeon Lee, Vinit B Mahajan, Charles DeBoer   |   Curr Ophthalmol Rep   |   Details
Ophthalmic drug discovery and development using artificial intelligence and digital health technologies   |   Haoran Cheng, Joy Le Yi Wong, Chrystie Wan Ning Quek, Jeffrey L Goldberg, Vinit B Mahajan, Tien Yin Wong, Jodhbir S Mehta, Daniel S W Ting, Darren S J Ting   |   NPJ Digit Med   |   Details
Protocol to extract tear fluid for proteomics using Schirmer strips   |   Ngo GH, Chadha M, Sun YJ, Yu G, Lee SH, Yeh TC, Almeida DRP, Bassuk AG, Mruthyunjaya P, Dufour A, Mahajan VB   |   Star Protocol   |   Details
In-clinic vitreous biopsy peel pack technique   |   DeBoer C, Zhao C, Mruthyunjaya P, Mahajan VB, Wai KM, Sanislo SR.   |   Int J Retina Vitreous   |   Details
Automated animal gimbal steering for retinal imaging and stimulation   |   Kunala K, Ayubi GA, Franco JA, Mahajan VB, Dubra A   |   Biomed Opt Express   |   Details

2024

Emerging Oral Pharmaceuticals for Dry Age-Related Macular Degeneration: Mechanism of Action, Current Clinical Status, and Future Directions   |   Charles M T DeBoer, Ditte K Rasmussen, Joel A Franco, Vinit B Mahajan   |   Ophthalmic Surg Lasers Imaging Retina   |   Details

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