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Phenomics Lab

High-throughput solutions for large-scale disease phenotyping.

We have established scalable, high-throughput phenotyping methods for characterizing human and mouse eye diseases. The mouse eye phenotype screening service is available to laboratories throughout the world. Through the development of cooperative laboratory networks, we hope to expand our screening effort.

Projects

We have established a scalable, multilevel, high-throughput phenotyping laboratory to identify mouse models for eye disease.

Capturing surgical events for careful clinical studies has always been a challenge.

News

Aug 19 2020 | Posted In: 20/20 Blog
Palo Alto, CA — Retinal detachment surgery is an emergency procedure that prevents blindness, but research from Stanford’s Byers Eye Institute shows women may be treated differently than men.
Jun 15 2020 | Posted In: 20/20 Blog
Palo Alto, CA — Despite the near complete shutdown of in-person laboratory activities at the beginning of the COVID-19 pandemic, the Stanford Ophthalmology research laboratories remain incredibly productive.
Apr 29 2020 | Posted In: 20/20 Blog
Palo Alto, CA — Traumatic brain injuries (TBI) can happen when someone is close to an explosion that sends out powerful shock waves through the air.
Feb 5 2020 | Posted In: 20/20 Blog
Palo Alto, CA — Glaucoma is a common eye disease due to degeneration of the optic nerve, and eye pressure is an important risk factor. There are limited therapies since it is difficult to model glaucoma in the lab.
Oct 14 2019 | Posted In: 20/20 Blog
Palo Alto, CA – Dry macular degeneration is a common eye condition that usually occurs in people over 50. It is characterized by blurring of the central vision along with a decreased ability to see colors and fine details.

Publications

Phenotypic variance in Calpain-5 retinal degeneration., Tang, Peter H., Chemudupati Teja, Wert Katherine J., Folk James C., Mahajan Maryann, Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , Am J Ophthalmol Case Rep, 2020 Jun, Volume 18, p.100627, (2020)
Missense mutation in SLIT2 associated with congenital myopia, anisometropia, connective tissue abnormalities, and obesity, Liu, Katherine Y., Sengillo Jesse D., Velez Gabriel, Jauregui Ruben, Sakai Lynn Y., Maumenee Irene H., Bassuk Alexander G., Mahajan Vinit B., and Tsang Stephen H. , Orphanet journal of rare diseases, Volume 13, p.138, (2018)
Extracellular superoxide dismutase 3 (SOD3) regulates oxidative stress at the vitreoretinal interface, Wert, Katherine J., Velez Gabriel, Cross Madeline R., Wagner Brett A., Teoh-Fitzgerald Melissa L., Buettner Garry R., McAnany Jason, Olivier Alicia, Tsang Stephen H., Harper Matthew M., et al. , Free Radical Biology and Medicine, (2018)
Retrospective Analysis of Structural Disease Progression in Retinitis Pigmentosa Utilizing Multimodal Imaging, Cabral, Thiago, Sengillo Jesse D., Duong Jimmy K., Justus Sally, Boudreault Katherine, Schuerch Kaspar, Belfort Rubens, Mahajan Vinit B., Sparrow Janet R., and Tsang Stephen H. , Scientific reports, Volume 7, Number 1, p.10347, (2017)
Proteomic analysis of elevated intraocular pressure with retinal detachment, Velez, Gabriel, C Roybal Nathaniel, Binkley Elaine, Bassuk Alexander G., Tsang Stephen H., and Mahajan Vinit B. , American journal of ophthalmology case reports, Volume 5, p.107–110, (2017)
Gene Therapy Restores Mfrp and Corrects Axial Eye Length, Velez, Gabriel, Tsang Stephen H., Tsai Yi-Ting, Hsu Chun-Wei, Gore Anuradha, Abdelhakim Aliaa H., Mahajan Maryann, Silverman Ronald H., Sparrow Janet R., Bassuk Alexander G., et al. , Scientific reports, Volume 7, p.16151, (2017)