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Phenomics Lab

High-throughput solutions for large-scale disease phenotyping.

We have established scalable, high-throughput phenotyping methods for characterizing human and mouse eye diseases. The mouse eye phenotype screening service is available to laboratories throughout the world. Through the development of cooperative laboratory networks, we hope to expand our screening effort.

Projects

We have established a scalable, multilevel, high-throughput phenotyping laboratory to identify mouse models for eye disease.

Capturing surgical events for careful clinical studies has always been a challenge.

News

Oct 14 2019 | Posted In: 20/20 Blog
Palo Alto, CA – Dry macular degeneration is a common eye condition that usually occurs in people over 50. It is characterized by blurring of the central vision along with a decreased ability to see colors and fine details.
Mar 14 2019 | Posted In: 20/20 Blog
Palo Alto, CA — Vinit Mahajan, M.D., Ph.D., Associate Professor of Ophthalmology in Stanford University School of Medicine’s Department of Ophthalmology, believes that eye tissue
Dec 14 2018 | Posted In: 20/20 Blog
Palo Alto, CA — Why volunteer for a clinical trial? The rigorous process of turning a new therapy into the standard of care depends on patient volunteers. 
Oct 27 2018 | Posted In: 20/20 Blog
Chicago, IL —Angela Li, a second year Stanford medical student working in the Mahajan lab, presented a poster, “Proteomic Analysis of Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy,” at the 2018 American Academy of Ophthalmology (AAO) m
Sep 26 2018 | Posted In: 20/20 Blog
Palo Alto, CA — Physicians, scientists, engineers, entrepreneurs, and patients are collaborating in an effort to move ophthalmology away from symptom-based, trial and error approaches to personalized treatment plans. 

Publications

Extracellular superoxide dismutase 3 (SOD3) regulates oxidative stress at the vitreoretinal interface, Wert, Katherine J., Velez Gabriel, Cross Madeline R., Wagner Brett A., Teoh-Fitzgerald Melissa L., Buettner Garry R., McAnany Jason, Olivier Alicia, Tsang Stephen H., Harper Matthew M., et al. , Free Radical Biology and Medicine, (2018)
Missense mutation in SLIT2 associated with congenital myopia, anisometropia, connective tissue abnormalities, and obesity, Liu, Katherine Y., Sengillo Jesse D., Velez Gabriel, Jauregui Ruben, Sakai Lynn Y., Maumenee Irene H., Bassuk Alexander G., Mahajan Vinit B., and Tsang Stephen H. , Orphanet journal of rare diseases, Volume 13, p.138, (2018)
Electroretinography Reveals Difference in Cone Function between Syndromic and Nonsyndromic USH2A Patients, Sengillo, Jesse D., Cabral Thiago, Schuerch Kaspar, Duong Jimmy, Lee Winston, Boudreault Katherine, Xu Yu, Justus Sally, Sparrow Janet R., Mahajan Vinit B., et al. , Scientific reports, Volume 7, Number 1, p.11170, (2017)
Calpain-5 gene expression in the mouse eye and brain, Schaefer, Kellie, Mahajan Maryann, Gore Anuradha, Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , BMC research notes, Volume 10, Number 1, p.602, (2017)
Retrospective Analysis of Structural Disease Progression in Retinitis Pigmentosa Utilizing Multimodal Imaging, Cabral, Thiago, Sengillo Jesse D., Duong Jimmy K., Justus Sally, Boudreault Katherine, Schuerch Kaspar, Belfort Rubens, Mahajan Vinit B., Sparrow Janet R., and Tsang Stephen H. , Scientific reports, Volume 7, Number 1, p.10347, (2017)
Proteomic analysis of elevated intraocular pressure with retinal detachment, Velez, Gabriel, C Roybal Nathaniel, Binkley Elaine, Bassuk Alexander G., Tsang Stephen H., and Mahajan Vinit B. , American journal of ophthalmology case reports, Volume 5, p.107–110, (2017)