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Phenomics Lab

High-throughput solutions for large-scale disease phenotyping.

We have established scalable, high-throughput phenotyping methods for characterizing human and mouse eye diseases. The mouse eye phenotype screening service is available to laboratories throughout the world. Through the development of cooperative laboratory networks, we hope to expand our screening effort.

Projects

We have established a scalable, multilevel, high-throughput phenotyping laboratory to identify mouse models for eye disease.

Capturing surgical events for careful clinical studies has always been a challenge.

News

Apr 29 2020 | Posted In: 20/20 Blog
Palo Alto, CA — Traumatic brain injuries (TBI) can happen when someone is close to an explosion that sends out powerful shock waves through the air.
Feb 5 2020 | Posted In: 20/20 Blog
Palo Alto, CA — Glaucoma is a common eye disease due to degeneration of the optic nerve, and eye pressure is an important risk factor. There are limited therapies since it is difficult to model glaucoma in the lab.
Oct 14 2019 | Posted In: 20/20 Blog
Palo Alto, CA – Dry macular degeneration is a common eye condition that usually occurs in people over 50. It is characterized by blurring of the central vision along with a decreased ability to see colors and fine details.
Mar 14 2019 | Posted In: 20/20 Blog
Palo Alto, CA — Vinit Mahajan, M.D., Ph.D., Associate Professor of Ophthalmology in Stanford University School of Medicine’s Department of Ophthalmology, believes that eye tissue
Dec 14 2018 | Posted In: 20/20 Blog
Palo Alto, CA — Why volunteer for a clinical trial? The rigorous process of turning a new therapy into the standard of care depends on patient volunteers. 
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Publications

Whole-Exome Sequencing of Patients with Posterior Segment Uveitis., Li, Angela S., Velez Gabriel, Darbro Benjamin, Toral Marcus A., Yang Jing, Tsang Stephen H., Ferguson Polly J., Folk James C., Bassuk Alexander G., and Mahajan Vinit B. , Am J Ophthalmol, 2020 Jul 21, (2020)
Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration., Wert, Katherine J., Velez Gabriel, Kanchustambham Vijaya L., Shankar Vishnu, Evans Lucy P., Sengillo Jesse D., Zare Richard N., Bassuk Alexander G., Tsang Stephen H., and Mahajan Vinit B. , EBioMedicine, 2020 Feb 03, Volume 52, p.102636, (2020)
Quantitative Autofluorescence Following Gene Therapy With Voretigene Neparvovec., Levi, Sarah R., Oh Jin Kyun, de Carvalho Jose Ronaldo Li, Mahajan Vinit B., Tsang Stephen H., and Sparrow Janet R. , JAMA Ophthalmol, 2020 Jun 18, (2020)
Molecular Surgery: Proteomics of a Rare Genetic Disease Gives Insight into Common Causes of Blindness., Velez, Gabriel, and Mahajan Vinit B. , iScience, 2020 Nov 20, Volume 23, Issue 11, p.101667, (2020)
Novel REEP6 gene mutation associated with autosomal recessive retinitis pigmentosa., Y., Lin, C.L. Xu, G. Velez, J. Yang, A.J. Tanaka, M.P. Breazzano, V.B. Mahajan, J.R. Sparrow, and S.H. Tsang , Doc Ophthalmol. 2020 Feb;140(1):67-75. doi: 10.1007/s10633-019-09719-1. Epub 2019 Sep 19., (2020)
Extracellular superoxide dismutase 3 (SOD3) regulates oxidative stress at the vitreoretinal interface, Wert, Katherine J., Velez Gabriel, Cross Madeline R., Wagner Brett A., Teoh-Fitzgerald Melissa L., Buettner Garry R., McAnany Jason, Olivier Alicia, Tsang Stephen H., Harper Matthew M., et al. , Free Radical Biology and Medicine, (2018)
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