We have established a scalable, multilevel, high-throughput phenotyping laboratory to identify mouse models for eye disease. The mouse eye phenotype screening service is available to laboratories throughout the world. In a series of pilot projects with gene trap, knockout and transgenic mice, collaborating laboratories receive our eye enucleation (removal) kits containing all the materials, instructions, and shipping supplies for the simple and rapid removal of mouse eyes. We are screening these eyes for disease phenotypes such as myopia, corneal opacity, glaucoma, cataract, retinal degeneration, retinal vascular disease, uveitis, and strabismus. Our preliminary screen has revealed several exciting prospects.
Through the development of cooperative laboratory networks, we hope to expand our screening effort. As our collaborator, we will keep you informed of our findings and will be honored to share authorship in any resulting publications. We believe some of the best opportunities for understanding and treating eye disease will come from the identification of mouse models. Please do not hesitate to contact us with any questions. We look forward to an interesting and productive collaboration.
The Mammalian Phenotype (MP) Ontology provides standard terms for annotating phenotypic data for all mammalian organs and tissues.