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Mouse Eye Phenomics

We have established a scalable, multilevel, high-throughput phenotyping laboratory to identify mouse models for eye disease. The mouse eye phenotype screening service is available to laboratories throughout the world. In a series of pilot projects with gene trap, knockout and transgenic mice, collaborating laboratories receive our eye enucleation (removal) kits containing all the materials, instructions, and shipping supplies for the simple and rapid removal of mouse eyes. We are screening these eyes for disease phenotypes such as myopia, corneal opacity, glaucoma, cataract, retinal degeneration, retinal vascular disease, uveitis, and strabismus. Our preliminary screen has revealed several exciting prospects.

Through the development of cooperative laboratory networks, we hope to expand our screening effort. As our collaborator, we will keep you informed of our findings and will be honored to share authorship in any resulting publications. We believe some of the best opportunities for understanding and treating eye disease will come from the identification of mouse models. Please do not hesitate to contact us with any questions. We look forward to an interesting and productive collaboration.


The Mammalian Phenotype (MP) Ontology provides standard terms for annotating phenotypic data for all mammalian organs and tissues.


Apr 5 2018 | Posted In: 20/20 Blog
Traumatic brain injury (TBI) is a leading cause of death and disability in the United States, with no currently available therapeutic interventions. We recently characterized histological changes in the eye using two different mouse models of TBI, a fluid percussion injury model and a blast injury...
Jun 16 2012 | Posted In: 20/20 Blog
An NIH grant to study oxidative stress enzymes in the vitreous has important implications for treating diabetic vitreoretinopathy.


Calpain-5 gene expression in the mouse eye and brain, Schaefer, Kellie, Mahajan Maryann, Gore Anuradha, Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , BMC research notes, Volume 10, Number 1, p.602, (2017)
Defective Motile Cilia in Prickle2-Deficient Mice., Sowers, Levi P., Yin Terry, Mahajan Vinit B., and Bassuk Alexander G. , J Neurogenet, 2014 Apr 7, (2014)
Mcph1-deficient mice reveal a role for MCPH1 in otitis media., Chen, Jing, Ingham Neil, Clare Simon, Raisen Claire, Vancollie Valerie E., Ismail Ozama, McIntyre Rebecca E., Tsang Stephen H., Mahajan Vinit B., Dougan Gordon, et al. , PLoS One, 2013, Volume 8, Issue 3, p.e58156, (2013)
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes., White, Jacqueline K., Gerdin Anna-Karin, Karp Natasha A., Ryder Ed, Buljan Marija, Bussell James N., Salisbury Jennifer, Clare Simon, Ingham Neil J., Podrini Christine, et al. , Cell, 2013 Jul 18, Volume 154, Issue 2, p.452-64, (2013)
Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome., McIntyre, Rebecca E., Chavali Pavithra Lakshminar, Ismail Ozama, Carragher Damian M., Sanchez-Andrade Gabriela, Forment Josep V., Fu Beiyuan, Velasco-Herrera Martin Del Castil, Edwards Andrew, van der Weyden Louise, et al. , PLoS Genet, 2012, Volume 8, Issue 11, p.e1003022, (2012)
Mutations in prickle orthologs cause seizures in flies, mice, and humans., Tao, Hirotaka, J Manak Robert, Sowers Levi, Mei Xue, Kiyonari Hiroshi, Abe Takaya, Dahdaleh Nader S., Yang Tian, Wu Shu, Chen Shan, et al. , American journal of human genetics, 2011 Feb 11, Volume 88, Issue 2, p.138-49, (2011)