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Surgical Phenomics

Capturing surgical events for careful clinical studies has always been a challenge. We have developed software instruments to rapidly investigate the benefits of new surgical treatments, educate new surgeons, and identify complications. 

By developing powerful databases with simplified access and query processes, we are linking the operating room to the laboratory and to clinical research teams. 

This structure has allowed high throughput interrogation of intraoperative features where we can quickly identify retinal phenotypes. The result is rapid identification of surgical complications, methods to avoid and treat complications, and correlations with molecular fingerprints that point to new therapeutic targets. 

Using these instruments, we have published several important peer-reviewed articles in medical journals.


Jun 21 2011 | Posted In: 20/20 Blog
We recently published a paper on our experience using the Retisert implant for sympathetic ophthalmia in the Journal Ophthalmology. Implantation into the eyes of eight patients stabilized vision, provided inflammatory control, and reduced dependence on systemic immunosuppression.


TEMPORAL APPROACH FOR SMALL-GAUGE PARS PLANA VITRECTOMY COMBINED WITH ANTERIOR SEGMENT SURGERY., Tarantola, Ryan M., Graff Jordan M., Somani Rizwan, and Mahajan Vinit B. , Retina (Philadelphia, Pa.), 2012 Apr 16, (2012)
Inhibition of Neovascularization but Not Fibrosis With the Fluocinolone Acetonide Implant in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy., Tlucek, Paul S., Folk James C., Orien Jason A., Stone Edwin M., and Mahajan Vinit B. , Archives of ophthalmology, 2012 Jul 9, p.1-7, (2012)
23-gauge pediatric vitrectomy using limbus-based trocar-cannulas., Kay, Christine N., Quiram Polly H., and Mahajan Vinit B. , Retina (Philadelphia, Pa.), 2012 May, Volume 32, Issue 5, p.1023-7, (2012)
Sutureless triplanar sclerotomy for 23-gauge vitrectomy., Mahajan, Vinit B., Tarantola Ryan M., Graff Jordan M., H Boldt Culver, Abràmoff Michael D., Russell Stephen R., and Folk James C. , Archives of ophthalmology, 2011 May, Volume 129, Issue 5, p.585-90, (2011)
INTRAOPERATIVE CHOROIDAL DETACHMENT DURING 23-GAUGE VITRECTOMY., Tarantola, Ryan M., Folk James C., Shah Shaival S., H Boldt Culver, Abràmoff Michael D., Russell Stephen R., and Mahajan Vinit B. , Retina (Philadelphia, Pa.), 2011 Jan 26, (2011)
Effects of vitrectomy on age-related macular degeneration., A Roller, Brock, Mahajan Vinit B., H Boldt Culver, Abràmoff Michael D., Russell Stephen R., and Folk James C. , Ophthalmology, 2010 Jul, Volume 117, Issue 7, p.1381-6, (2010)