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Phenomics Lab

High-throughput solutions for large-scale disease phenotyping.

We have established scalable, high-throughput phenotyping methods for characterizing human and mouse eye diseases. The mouse eye phenotype screening service is available to laboratories throughout the world. Through the development of cooperative laboratory networks, we hope to expand our screening effort.

Projects

We have established a scalable, multilevel, high-throughput phenotyping laboratory to identify mouse models for eye disease.

Capturing surgical events for careful clinical studies has always been a challenge.

News

| Posted In: 20/20 Blog
We collaborated with scientists to test software that automatically identifies fundus features of diabetic retinopathy. This technology is being commercialized with the hope of bringing eye care to underserved populations.

Publications

Proteomic analysis of elevated intraocular pressure with retinal detachment, Velez, Gabriel, C Roybal Nathaniel, Binkley Elaine, Bassuk Alexander G., Tsang Stephen H., and Mahajan Vinit B. , American journal of ophthalmology case reports, Volume 5, p.107–110, (2017)
Comparison of microbiology and visual outcomes of patients undergoing small-gauge and 20-gauge vitrectomy for endophthalmitis., Almeida, David R. P., Chin Eric K., Shah Shaival S., Bakall Benjamin, Gehrs Karen M., H Boldt Culver, Russell Stephen R., Folk James C., and Mahajan Vinit B. , Clin Ophthalmol, 2016, Volume 10, p.167-72, (2016)
Defective Motile Cilia in Prickle2-Deficient Mice., Sowers, Levi P., Yin Terry, Mahajan Vinit B., and Bassuk Alexander G. , J Neurogenet, 2014 Apr 7, (2014)
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes., White, Jacqueline K., Gerdin Anna-Karin, Karp Natasha A., Ryder Ed, Buljan Marija, Bussell James N., Salisbury Jennifer, Clare Simon, Ingham Neil J., Podrini Christine, et al. , Cell, 2013 Jul 18, Volume 154, Issue 2, p.452-64, (2013)
Mcph1-deficient mice reveal a role for MCPH1 in otitis media., Chen, Jing, Ingham Neil, Clare Simon, Raisen Claire, Vancollie Valerie E., Ismail Ozama, McIntyre Rebecca E., Tsang Stephen H., Mahajan Vinit B., Dougan Gordon, et al. , PLoS One, 2013, Volume 8, Issue 3, p.e58156, (2013)
Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome., McIntyre, Rebecca E., Chavali Pavithra Lakshminar, Ismail Ozama, Carragher Damian M., Sanchez-Andrade Gabriela, Forment Josep V., Fu Beiyuan, Velasco-Herrera Martin Del Castil, Edwards Andrew, van der Weyden Louise, et al. , PLoS Genet, 2012, Volume 8, Issue 11, p.e1003022, (2012)