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Phenomics Lab

High-throughput solutions for large-scale disease phenotyping.

We have established scalable, high-throughput phenotyping methods for characterizing human and mouse eye diseases. The mouse eye phenotype screening service is available to laboratories throughout the world. Through the development of cooperative laboratory networks, we hope to expand our screening effort.

Projects

We have established a scalable, multilevel, high-throughput phenotyping laboratory to identify mouse models for eye disease.

Capturing surgical events for careful clinical studies has always been a challenge.

News

Sep 30 2021 | Posted In: 20/20 Blog
 
Jul 6 2021 | Posted In: 20/20 Blog
Palo Alto, CA – As genetic testing and molecular biomarkers open new avenues for medical care, researchers are more reliant on samples from human subjects than ever.
Aug 19 2020 | Posted In: 20/20 Blog
Palo Alto, CA — Retinal detachment surgery is an emergency procedure that prevents blindness, but research from Stanford’s Byers Eye Institute shows women may be treated differently than men.
Jun 15 2020 | Posted In: 20/20 Blog
Palo Alto, CA — Despite the near complete shutdown of in-person laboratory activities at the beginning of the COVID-19 pandemic, the Stanford Ophthalmology research laboratories remain incredibly productive.
Jun 8 2020 | Posted In: 20/20 Blog, Press
Palo Alto, Ca — Genetic testing doesn’t always provide a diagnosis, so Vinit Mahajan M.D., Ph.D., professor of ophthalmology at Stanford University, has applied proteomics to better understand disease in his patients. 
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Publications

Phenotypic variance in Calpain-5 retinal degeneration., Tang, Peter H., Chemudupati Teja, Wert Katherine J., Folk James C., Mahajan Maryann, Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , Am J Ophthalmol Case Rep, 2020 Jun, Volume 18, p.100627, (2020)
Intravitreal methotrexate and fluocinolone acetonide implantation for Vogt-Koyanagi-Harada uveitis., Park, Jong G., Callaway Natalia F., Ludwig Cassie A., and Mahajan Vinit B. , Am J Ophthalmol Case Rep, 2020 Sep, Volume 19, p.100859, (2020)
Proteomic analysis of intermediate uveitis suggests myeloid cell recruitment and implicates IL-23 as a therapeutic target., Sepah, Yasir J., Velez Gabriel, Tang Peter H., Yang Jing, Chemudupati Teja, Li Angela S., Nguyen Quan D., Bassuk Alexander G., and Mahajan Vinit B. , Am J Ophthalmol Case Rep, 2020 Jun, Volume 18, p.100646, (2020)
Whole-Exome Sequencing of Patients with Posterior Segment Uveitis., Li, Angela S., Velez Gabriel, Darbro Benjamin, Toral Marcus A., Yang Jing, Tsang Stephen H., Ferguson Polly J., Folk James C., Bassuk Alexander G., and Mahajan Vinit B. , Am J Ophthalmol, 2020 Jul 21, (2020)
Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration., Wert, Katherine J., Velez Gabriel, Kanchustambham Vijaya L., Shankar Vishnu, Evans Lucy P., Sengillo Jesse D., Zare Richard N., Bassuk Alexander G., Tsang Stephen H., and Mahajan Vinit B. , EBioMedicine, 2020 Feb 03, Volume 52, p.102636, (2020)
Quantitative Autofluorescence Following Gene Therapy With Voretigene Neparvovec., Levi, Sarah R., Oh Jin Kyun, de Carvalho Jose Ronaldo Li, Mahajan Vinit B., Tsang Stephen H., and Sparrow Janet R. , JAMA Ophthalmol, 2020 Jun 18, (2020)
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