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Human Microsurgery

We use evidence-based approaches to study and improve surgery for our patients. Once surgeons and scientists have a molecular target in their sights, numerous molecular drugs are available to them. These may involve enzymes, genes, antibodies, or chemicals. Eye surgeons can precisely and safely deliver any of these molecules near specific cells in the eye, avoiding the toxicity and issues associated with drugs taken by mouth or injected into the blood stream. Once delivered, patients can be observed noninvasively in the clinic using ultra-high-resolution cameras.

Projects

A multi-institution precision health consortium for collecting ophthalmic surgical samples.

We conducted laboratory and clinical studies on macular hole repair.

We conduct studies to develop safer, more efficient surgery in patients.

Evidence-based approaches for new surgical treatments and research to discover the molecular causes.

News

May 6 2021 | Posted In: 20/20 Blog
Palo Alto, CA — Most people today, including many physicians, see the hypodermic needle as a mundane instrument that isn’t worth a second thought. This is not so for eye surgeons.
Apr 1 2021 | Posted In: 20/20 Blog
Palo Alto, CA —Through funding from The Cancer League, a local cancer charity, Prithvi Mruthyunjaya MD, MHS and  Vinit Mahajan MD, PhD
Jan 11 2021 | Posted In: 20/20 Blog
Palo Alto, CA — The Mahajan Lab is designing small-molecule injectable drugs for a number of molecular targets they identified using proteomics, the large-scale study of proteins
Aug 19 2020 | Posted In: 20/20 Blog
Palo Alto, CA — Retinal detachment surgery is an emergency procedure that prevents blindness, but research from Stanford’s Byers Eye Institute shows women may be treated differently than men.
Jun 15 2020 | Posted In: 20/20 Blog
Palo Alto, CA — Despite the near complete shutdown of in-person laboratory activities at the beginning of the COVID-19 pandemic, the Stanford Ophthalmology research laboratories remain incredibly productive.

Publications

Quantitative progression of retinitis pigmentosa by optical coherence tomography angiography, Jauregui, Ruben, Park Karen Sophia, Duong Jimmy K., Mahajan Vinit B., and Tsang Stephen H. , Scientific reports, Volume 8, p.13130, (2018)
Autologous stem cell therapy for inherited and acquired retinal disease, Apatoff, Mary Ben L., Sengillo Jesse D., White Eugenia C., Bakhoum Mathieu F., Bassuk Alexander G., Mahajan Vinit B., and Tsang Stephen H. , Regenerative medicine, (2018)
Personalized Proteomics for Precision Health: Identifying Biomarkers of Vitreoretinal Disease., Velez, Gabriel, Tang Peter H., Cabral Thiago, Cho Galaxy Y., Machlab Daniel A., Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , Transl Vis Sci Technol, 2018 Sep, Volume 7, Issue 5, p.12, (2018)
Limbal Trocar-Cannulas for Complex Vitrectomy Surgery., Mears, Katrina A., and Mahajan Vinit B. , Retina, 2017 Jul 21, (2017)
Dissection of Human Retina and RPE-Choroid for Proteomic Analysis., Cabral, Thiago, Toral Marcus A., Velez Gabriel, DiCarlo James E., Gore Anuradha M., Mahajan M, Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , Journal of visualized experiments: JoVE, (2017)
COMBINED VITRECTOMY AND INTRAVITREAL DEXAMETHASONE (OZURDEX) SUSTAINED-RELEASE IMPLANT., Zheng, Andrew, Chin Eric K., Almeida David R. P., Tsang Stephen H., and Mahajan Vinit B. , Retina, 2016 Nov, Volume 36, Issue 11, p.2087-2092, (2016)