Title | Personalized Proteomics for Precision Health: Identifying Biomarkers of Vitreoretinal Disease. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Velez, Gabriel, Tang Peter H., Cabral Thiago, Cho Galaxy Y., Machlab Daniel A., Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. |
Journal | Transl Vis Sci Technol |
Volume | 7 |
Issue | 5 |
Pagination | 12 |
Date Published | 2018 Sep |
ISSN | 2164-2591 |
Abstract | Proteomic analysis is an attractive and powerful tool for characterizing the molecular profiles of diseased tissues, such as the vitreous. The complexity of data available for analysis ranges from single (e.g., enzyme-linked immunosorbent assay [ELISA]) to thousands (e.g., mass spectrometry) of proteins, and unlike genomic analysis, which is limited to denoting risk, proteomic methods take snapshots of a diseased vitreous to evaluate ongoing molecular processes in real time. The proteome of diseased ocular tissues was recently characterized, uncovering numerous biomarkers for vitreoretinal diseases and identifying protein targets for approved drugs, allowing for drug repositioning. These biomarkers merit more attention regarding their therapeutic potential and prospective validation, as well as their value as reproducible, sensitive, and specific diagnostic markers. Translational Relevance: Personalized proteomics offers many advantages over alternative precision-health platforms for the diagnosis and treatment of vitreoretinal diseases, including identification of molecular constituents in the diseased tissue that can be targeted by available drugs. |
DOI | 10.1167/tvst.7.5.12 |
Alternate Journal | Transl Vis Sci Technol |
PubMed ID | 30271679 |
PubMed Central ID | PMC6159735 |
Grant List | R21 AG050437 / AG / NIA NIH HHS / United States R01 EY018213 / EY / NEI NIH HHS / United States R01 EY024665 / EY / NEI NIH HHS / United States R01 EY026682 / EY / NEI NIH HHS / United States R01 EY024698 / EY / NEI NIH HHS / United States P30 EY019007 / EY / NEI NIH HHS / United States R01 EY025225 / EY / NEI NIH HHS / United States P30 CA013696 / CA / NCI NIH HHS / United States T32 GM007337 / GM / NIGMS NIH HHS / United States |