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Proteomics Lab

Proteomics is the culmination of advances in chemistry, physics, bioinformatics, and molecular biology that allow the study of thousands of proteins simultaneously. A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest. This strategy is especially important in eye diseases where there are limited cell and animal models.

We are using proteomics to discover biomarkers, therapeutic targets, and molecular pathways involved in several eye diseases where diagnosis is difficult and current treatment is inadequate.

Projects

A multi-institution precision health consortium for collecting ophthalmic surgical samples.

We are using proteomics to study the vitreous fluid from eyes with ADNIV.

A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest.

The vitreous is an optically clear, collagenous extracellular matrix that fills the inside of the eye and overlies the retina.

News

May 31 2019 | Posted In: 20/20 Blog
Palo Alto, CA – What is myopic degeneration?
May 15 2019 | Posted In: 20/20 Blog
Palo Alto, CA – What is genetic testing?
Apr 19 2019 | Posted In: 20/20 Blog
Palo Alto, CA — Mahajan lab members Gabriel Velez and Teja Chemudupati presented their latest research on choroidal melanoma at the 2019 Inaugural Byers Young Investigator Research Conference. Research topics included clinical trials, digital health, and basic translational research. 
Mar 22 2019 | Posted In: 20/20 Blog
Roanoke, VA – Dr. Vinit Mahajan M.D., Ph.D., associate professor in Stanford University’s Department of Ophthalmology, highlighted his work in translational medicine in a Timothy A.
Mar 14 2019 | Posted In: 20/20 Blog
Palo Alto, CA — Vinit Mahajan, M.D., Ph.D., Associate Professor of Ophthalmology in Stanford University School of Medicine’s Department of Ophthalmology, believes that eye tissue

Publications

Retinal and choroidal angiogenesis: a review of new targets, Cabral, Thiago, Mello Luiz Guilherme, Lima Luiz H., Polido Júlia, Regatieri Caio V., Belfort Rubens, and Mahajan Vinit B. , International journal of retina and vitreous, Volume 3, Number 1, p.31, (2017)
Personalized proteomics in proliferative vitreoretinopathy implicate hematopoietic cell recruitment and mTOR as a therapeutic target, C Roybal, Nathaniel, Velez Gabriel, Toral Marcus A., Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , American journal of ophthalmology, (2017)
Proteomic analysis of elevated intraocular pressure with retinal detachment, Velez, Gabriel, C Roybal Nathaniel, Binkley Elaine, Bassuk Alexander G., Tsang Stephen H., and Mahajan Vinit B. , American journal of ophthalmology case reports, Volume 5, p.107–110, (2017)
Therapeutic drug repositioning using personalized proteomics of liquid biopsies, Velez, Gabriel, Bassuk Alexander G., Colgan Diana, Tsang Stephen H., and Mahajan Vinit B. , JCI insight, Volume 2, (2017)
Translational vitreous proteomics., Mahajan, Vinit B., and Skeie Jessica M. , Proteomics Clin Appl, 2013 Sep 24, (2013)
Proteomic interactions in the mouse vitreous-retina complex., Skeie, Jessica M., and Mahajan Vinit B. , PLoS One, 2013, Volume 8, Issue 11, p.e82140, (2013)