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Proteomics Lab

Proteomics is the culmination of advances in chemistry, physics, bioinformatics, and molecular biology that allow the study of thousands of proteins simultaneously. A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest. This strategy is especially important in eye diseases where there are limited cell and animal models.

We are using proteomics to discover biomarkers, therapeutic targets, and molecular pathways involved in several eye diseases where diagnosis is difficult and current treatment is inadequate.

Projects

A multi-institution precision health consortium for collecting ophthalmic surgical samples.

We are using proteomics to study the vitreous fluid from eyes with ADNIV.

A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest.

The vitreous is an optically clear, collagenous extracellular matrix that fills the inside of the eye and overlies the retina.

News

Mar 22 2019 | Posted In: 20/20 Blog
Roanoke, VA – Dr. Vinit Mahajan M.D., Ph.D., associate professor in Stanford University’s Department of Ophthalmology, highlighted his work in translational medicine in a Timothy A.
Mar 14 2019 | Posted In: 20/20 Blog
Palo Alto, CA — Vinit Mahajan, M.D., Ph.D., Associate Professor of Ophthalmology in Stanford University School of Medicine’s Department of Ophthalmology, believes that eye tissue
Feb 4 2019 | Posted In: 20/20 Blog
Palo Alto, CA — How can physicians and scientists make clinical trials faster, cheaper, and more likely to succeed? The answer may be proteomic analysis.
Nov 13 2018 | Posted In: 20/20 Blog
Palo Alto, CA — When Daniel Machlab, a bioengineering student in the Mahajan lab, started working on large proteomics datasets, he noticed a problem. Conventional software processing resulted in the scattered loss of several data points among the millions of data points identified.
Oct 27 2018 | Posted In: 20/20 Blog
Chicago, IL —Angela Li, a second year Stanford medical student working in the Mahajan lab, presented a poster, “Proteomic Analysis of Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy,” at the 2018 American Academy of Ophthalmology (AAO) m

Publications

Dissection of Human Retina and RPE-Choroid for Proteomic Analysis., Cabral, Thiago, Toral Marcus A., Velez Gabriel, DiCarlo James E., Gore Anuradha M., Mahajan M, Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , Journal of visualized experiments: JoVE, (2017)
Gene Therapy Restores Mfrp and Corrects Axial Eye Length, Velez, Gabriel, Tsang Stephen H., Tsai Yi-Ting, Hsu Chun-Wei, Gore Anuradha, Abdelhakim Aliaa H., Mahajan Maryann, Silverman Ronald H., Sparrow Janet R., Bassuk Alexander G., et al. , Scientific reports, Volume 7, p.16151, (2017)
Retinal and choroidal angiogenesis: a review of new targets, Cabral, Thiago, Mello Luiz Guilherme, Lima Luiz H., Polido Júlia, Regatieri Caio V., Belfort Rubens, and Mahajan Vinit B. , International journal of retina and vitreous, Volume 3, Number 1, p.31, (2017)
Personalized proteomics in proliferative vitreoretinopathy implicate hematopoietic cell recruitment and mTOR as a therapeutic target, C Roybal, Nathaniel, Velez Gabriel, Toral Marcus A., Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , American journal of ophthalmology, (2017)
PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders., Paemka, Lily, Mahajan Vinit B., Skeie Jessica M., Sowers Levi P., Ehaideb Salleh N., Gonzalez-Alegre Pedro, Sasaoka Toshikuni, Tao Hirotaka, Miyagi Asuka, Ueno Naoto, et al. , PLoS One, 2013, Volume 8, Issue 12, p.e80737, (2013)
A biorepository for ophthalmic surgical specimens., Skeie, Jessica M., Tsang Stephen H., Zande Ryan Vande, Fickbohm Macy M., Shah Shaival S., Vallone John G., and Mahajan Vinit B. , Proteomics Clin Appl, 2013 Sep 24, (2013)