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Proteomics Lab

Proteomics is the culmination of advances in chemistry, physics, bioinformatics, and molecular biology that allow the study of thousands of proteins simultaneously. A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest. This strategy is especially important in eye diseases where there are limited cell and animal models.

We are using proteomics to discover biomarkers, therapeutic targets, and molecular pathways involved in several eye diseases where diagnosis is difficult and current treatment is inadequate.

Projects

A multi-institution precision health consortium for collecting ophthalmic surgical samples.

We are using proteomics to study the vitreous fluid from eyes with ADNIV.

A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest.

The vitreous is an optically clear, collagenous extracellular matrix that fills the inside of the eye and overlies the retina.

News

Apr 18 2022 | Posted In: 20/20 Blog, Press
Palo Alto, CA — A Wall Street Journal article on age-related retinal tears and detachments features an interview with Stanford’s Vinit Mahajan MD, PhD, professor of ophthalmology and vice chair for
Sep 30 2021 | Posted In: 20/20 Blog
 
Jul 6 2021 | Posted In: 20/20 Blog
Palo Alto, CA – As genetic testing and molecular biomarkers open new avenues for medical care, researchers are more reliant on samples from human subjects than ever.
Jun 28 2021 | Posted In: 20/20 Blog
Palo Alto, CA ­— Jennifer Vu, a recent Stanford graduate and researcher in the Mahajan Lab, earned the 2021 Oral Communication Program Excellence in Honors Thesis Presentation Award. 
May 6 2021 | Posted In: 20/20 Blog
Palo Alto, CA — Most people today, including many physicians, see the hypodermic needle as a mundane instrument that isn’t worth a second thought. This is not so for eye surgeons.
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Publications

Molecular Characterization of a Rare Case of Bilateral Vitreoretinal T Cell Lymphoma through Vitreous Liquid Biopsy., Cani, Andi K., Toral Marcus A., Balikov Daniel A., Betz Bryan L., Hu Kevin, Liu Chia-Jen, Prifti Matthew V., Chinnaiyan Arul M., Tomlins Scott A., Mahajan Vinit B., et al. , Int J Mol Sci, 2021 Jun 05, Volume 22, Issue 11, (2021)
Liquid biopsy proteomics of uveal melanoma reveals biomarkers associated with metastatic risk., Velez, Gabriel, Nguyen Huy V., Chemudupati Teja, Ludwig Cassie A., Toral Marcus, Reddy Sunil, Mruthyunjaya Prithvi, and Mahajan Vinit B. , Mol Cancer, 2021 02 24, Volume 20, Issue 1, p.39, (2021)
Molecular Surgery: Proteomics of a Rare Genetic Disease Gives Insight into Common Causes of Blindness., Velez, Gabriel, and Mahajan Vinit B. , iScience, 2020 Nov 20, Volume 23, Issue 11, p.101667, (2020)
Proteomic analysis of intermediate uveitis suggests myeloid cell recruitment and implicates IL-23 as a therapeutic target., Sepah, Yasir J., Velez Gabriel, Tang Peter H., Yang Jing, Chemudupati Teja, Li Angela S., Nguyen Quan D., Bassuk Alexander G., and Mahajan Vinit B. , Am J Ophthalmol Case Rep, 2020 Jun, Volume 18, p.100646, (2020)
Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration., Wert, Katherine J., Velez Gabriel, Kanchustambham Vijaya L., Shankar Vishnu, Evans Lucy P., Sengillo Jesse D., Zare Richard N., Bassuk Alexander G., Tsang Stephen H., and Mahajan Vinit B. , EBioMedicine, 2020 Feb 03, Volume 52, p.102636, (2020)
Personalized Proteomics for Precision Health: Identifying Biomarkers of Vitreoretinal Disease., Velez, Gabriel, Tang Peter H., Cabral Thiago, Cho Galaxy Y., Machlab Daniel A., Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , Transl Vis Sci Technol, 2018 Sep, Volume 7, Issue 5, p.12, (2018)
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