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Proteomics Lab

Proteomics is the culmination of advances in chemistry, physics, bioinformatics, and molecular biology that allow the study of thousands of proteins simultaneously. A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest. This strategy is especially important in eye diseases where there are limited cell and animal models.

We are using proteomics to discover biomarkers, therapeutic targets, and molecular pathways involved in several eye diseases where diagnosis is difficult and current treatment is inadequate.

Projects

A multi-institution precision health consortium for collecting ophthalmic surgical samples.

We are using proteomics to study the vitreous fluid from eyes with ADNIV.

A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest.

The vitreous is an optically clear, collagenous extracellular matrix that fills the inside of the eye and overlies the retina.

News

Jul 8 2019 | Posted In: 20/20 Blog
Palo Alto, CA – Vinit Mahajan M.D., Ph.D., Stanford vitreoretinal surgeon and Vice Chair of Research in the department of ophthalmology, gave an overview on molecular therapies at the 2019 Stanford’s Bay Area Ophthalmology Course
Jun 19 2019 | Posted In: 20/20 Blog, Press
Palo Alto, CA - Vinit Mahajan M.D., Ph.D., Stanford vitreoretinal surgeon and Vice Chair of Research in the department of ophthalmology, was recently featured in the article, “
Jun 4 2019
Palo Alto, CA – Calling a disease orphan, or rare, can be misleading considering millions of Americans suffer from thousands of orphan diseases that are often serious or life threatening.
Jun 4 2019 | Posted In: 20/20 Blog
Palo Alto, CA – Calling a disease orphan, or rare, can be misleading considering millions of Americans suffer from thousands of orphan diseases that are often serious or life threatening.
May 31 2019 | Posted In: 20/20 Blog
Palo Alto, CA – What is myopic degeneration?

Publications

Personalized proteomics in proliferative vitreoretinopathy implicate hematopoietic cell recruitment and mTOR as a therapeutic target, C Roybal, Nathaniel, Velez Gabriel, Toral Marcus A., Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , American journal of ophthalmology, (2017)
Proteomic analysis of elevated intraocular pressure with retinal detachment, Velez, Gabriel, C Roybal Nathaniel, Binkley Elaine, Bassuk Alexander G., Tsang Stephen H., and Mahajan Vinit B. , American journal of ophthalmology case reports, Volume 5, p.107–110, (2017)
Therapeutic drug repositioning using personalized proteomics of liquid biopsies, Velez, Gabriel, Bassuk Alexander G., Colgan Diana, Tsang Stephen H., and Mahajan Vinit B. , JCI insight, Volume 2, (2017)
Dissection of Human Retina and RPE-Choroid for Proteomic Analysis., Cabral, Thiago, Toral Marcus A., Velez Gabriel, DiCarlo James E., Gore Anuradha M., Mahajan M, Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , Journal of visualized experiments: JoVE, (2017)
Translational vitreous proteomics., Mahajan, Vinit B., and Skeie Jessica M. , Proteomics Clin Appl, 2013 Sep 24, (2013)
Proteomic interactions in the mouse vitreous-retina complex., Skeie, Jessica M., and Mahajan Vinit B. , PLoS One, 2013, Volume 8, Issue 11, p.e82140, (2013)