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Proteomics Lab

Proteomics is the culmination of advances in chemistry, physics, bioinformatics, and molecular biology that allow the study of thousands of proteins simultaneously. A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest. This strategy is especially important in eye diseases where there are limited cell and animal models.

We are using proteomics to discover biomarkers, therapeutic targets, and molecular pathways involved in several eye diseases where diagnosis is difficult and current treatment is inadequate.

Projects

A multi-institution precision health consortium for collecting ophthalmic surgical samples.

We are using proteomics to study the vitreous fluid from eyes with ADNIV.

A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest.

The vitreous is an optically clear, collagenous extracellular matrix that fills the inside of the eye and overlies the retina.

News

Sep 16 2019 | Posted In: 20/20 Blog
Palo Alto, CA – The Molecular Surgery Program in Stanford’s Ophthalmology Department held the first Bay Area Genetic Retinal Disease Case Conference at the 
Sep 5 2019 | Posted In: 20/20 Blog, Press
Palo Alto, CA – The Stanford Ophthalmology Department highlighted its  clinical, surgical, and research achievements in its first annual report
Aug 13 2019 | Posted In: 20/20 Blog
Palo Alto, CA – An Ocular Melanoma Proteomics Symposium at Stanford University was hosted by Vinit Mahajan M.D., Ph.D., Vice Chair of Research in Ophthalmology, and Prithvi Mruthyun
Jul 19 2019 | Posted In: 20/20 Blog
Pacific Grove, CA – Every three years The Biology of Calpains in Health and Disease Conference brings together an international, multidisciplinary group of researchers who are examining the role calpains play in diseases like re
Jul 8 2019 | Posted In: 20/20 Blog
Palo Alto, CA – Vinit Mahajan M.D., Ph.D., Stanford vitreoretinal surgeon and Vice Chair of Research in the department of ophthalmology, gave an overview on molecular therapies at the 2019 Stanford’s Bay Area Ophthalmology Course

Publications

Therapeutic drug repositioning using personalized proteomics of liquid biopsies, Velez, Gabriel, Bassuk Alexander G., Colgan Diana, Tsang Stephen H., and Mahajan Vinit B. , JCI insight, Volume 2, (2017)
Dissection of Human Retina and RPE-Choroid for Proteomic Analysis., Cabral, Thiago, Toral Marcus A., Velez Gabriel, DiCarlo James E., Gore Anuradha M., Mahajan M, Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , Journal of visualized experiments: JoVE, (2017)
Gene Therapy Restores Mfrp and Corrects Axial Eye Length, Velez, Gabriel, Tsang Stephen H., Tsai Yi-Ting, Hsu Chun-Wei, Gore Anuradha, Abdelhakim Aliaa H., Mahajan Maryann, Silverman Ronald H., Sparrow Janet R., Bassuk Alexander G., et al. , Scientific reports, Volume 7, p.16151, (2017)
Retinal and choroidal angiogenesis: a review of new targets, Cabral, Thiago, Mello Luiz Guilherme, Lima Luiz H., Polido Júlia, Regatieri Caio V., Belfort Rubens, and Mahajan Vinit B. , International journal of retina and vitreous, Volume 3, Number 1, p.31, (2017)
Personalized proteomics in proliferative vitreoretinopathy implicate hematopoietic cell recruitment and mTOR as a therapeutic target, C Roybal, Nathaniel, Velez Gabriel, Toral Marcus A., Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , American journal of ophthalmology, (2017)
A biorepository for ophthalmic surgical specimens., Skeie, Jessica M., Tsang Stephen H., Zande Ryan Vande, Fickbohm Macy M., Shah Shaival S., Vallone John G., and Mahajan Vinit B. , Proteomics Clin Appl, 2013 Sep 24, (2013)