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Proteomic Pipelines for Precision Health

A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest. We use proteomics to discover biomarkers, therapeutic targets, and molecular pathways involved in eye diseases where diagnosis is difficult and current treatment is inadequate. Projects include the use of human tissues, animal tissues, and cultured cells.

Data sets from our studies are available as downloadable excel files (see links below). A search interface is under development. Publications are listed below.

Downloadable Proteomics Data Set Files (Not yet available).

Publications

A biorepository for ophthalmic surgical specimens., Skeie, Jessica M., Tsang Stephen H., Zande Ryan Vande, Fickbohm Macy M., Shah Shaival S., Vallone John G., and Mahajan Vinit B. , Proteomics Clin Appl, 2013 Sep 24, (2013)
Translational vitreous proteomics., Mahajan, Vinit B., and Skeie Jessica M. , Proteomics Clin Appl, 2013 Sep 24, (2013)
Proteomic interactions in the mouse vitreous-retina complex., Skeie, Jessica M., and Mahajan Vinit B. , PLoS One, 2013, Volume 8, Issue 11, p.e82140, (2013)
Proteomic analysis of vitreous biopsy techniques., Skeie, Jessica M., Brown Eric N., Martinez Harryl D., Russell Stephen R., Birkholz Emily S., Folk James C., H Boldt Culver, Gehrs Karen M., Stone Edwin M., Wright Michael E., et al. , Retina, 2012 Nov-Dec, Volume 32, Issue 10, p.2141-9, (2012)
Evisceration of mouse vitreous and retina for proteomic analyses., Skeie, Jessica M., Tsang Stephen H., and Mahajan Vinit B. , Journal of visualized experiments : JoVE, 2011, Issue 50, (2011)
Dissection of human vitreous body elements for proteomic analysis., Skeie, Jessica M., and Mahajan Vinit B. , Journal of visualized experiments : JoVE, 2011, Issue 47, (2011)