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Proteomics Lab

Proteomics is the culmination of advances in chemistry, physics, bioinformatics, and molecular biology that allow the study of thousands of proteins simultaneously. A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest. This strategy is especially important in eye diseases where there are limited cell and animal models.

We are using proteomics to discover biomarkers, therapeutic targets, and molecular pathways involved in several eye diseases where diagnosis is difficult and current treatment is inadequate.

Projects

A multi-institution precision health consortium for collecting ophthalmic surgical samples.

We are using proteomics to study the vitreous fluid from eyes with ADNIV.

A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest.

The vitreous is an optically clear, collagenous extracellular matrix that fills the inside of the eye and overlies the retina.

News

May 15 2019 | Posted In: 20/20 Blog
Palo Alto, CA – What is genetic testing?
Apr 19 2019 | Posted In: 20/20 Blog
Palo Alto, CA — Mahajan lab members Gabriel Velez and Teja Chemudupati presented their latest research on choroidal melanoma at the 2019 Inaugural Byers Young Investigator Research Conference. Research topics included clinical trials, digital health, and basic translational research. 
Mar 22 2019 | Posted In: 20/20 Blog
Roanoke, VA – Dr. Vinit Mahajan M.D., Ph.D., associate professor in Stanford University’s Department of Ophthalmology, highlighted his work in translational medicine in a Timothy A.
Mar 14 2019 | Posted In: 20/20 Blog
Palo Alto, CA — Vinit Mahajan, M.D., Ph.D., Associate Professor of Ophthalmology in Stanford University School of Medicine’s Department of Ophthalmology, believes that eye tissue
Feb 4 2019 | Posted In: 20/20 Blog
Palo Alto, CA — How can physicians and scientists make clinical trials faster, cheaper, and more likely to succeed? The answer may be proteomic analysis.

Publications

PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders., Paemka, Lily, Mahajan Vinit B., Skeie Jessica M., Sowers Levi P., Ehaideb Salleh N., Gonzalez-Alegre Pedro, Sasaoka Toshikuni, Tao Hirotaka, Miyagi Asuka, Ueno Naoto, et al. , PLoS One, 2013, Volume 8, Issue 12, p.e80737, (2013)
A biorepository for ophthalmic surgical specimens., Skeie, Jessica M., Tsang Stephen H., Zande Ryan Vande, Fickbohm Macy M., Shah Shaival S., Vallone John G., and Mahajan Vinit B. , Proteomics Clin Appl, 2013 Sep 24, (2013)
Dissection of human vitreous body elements for proteomic analysis., Skeie, Jessica M., and Mahajan Vinit B. , Journal of visualized experiments : JoVE, 2011, Issue 47, (2011)
Evisceration of mouse vitreous and retina for proteomic analyses., Skeie, Jessica M., Tsang Stephen H., and Mahajan Vinit B. , Journal of visualized experiments : JoVE, 2011, Issue 50, (2011)
Creatine kinase, an ATP-generating enzyme, is required for thrombin receptor signaling to the cytoskeleton., Mahajan, V B., Pai K S., Lau A, and Cunningham D D. , Proceedings of the National Academy of Sciences of the United States of America, 2000 Oct 24, Volume 97, Issue 22, p.12062-7, (2000)