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Proteomics Lab

Proteomics is the culmination of advances in chemistry, physics, bioinformatics, and molecular biology that allow the study of thousands of proteins simultaneously. A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest. This strategy is especially important in eye diseases where there are limited cell and animal models.

We are using proteomics to discover biomarkers, therapeutic targets, and molecular pathways involved in several eye diseases where diagnosis is difficult and current treatment is inadequate.

Projects

A multi-institution precision health consortium for collecting ophthalmic surgical samples.

We are using proteomics to study the vitreous fluid from eyes with ADNIV.

A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest.

The vitreous is an optically clear, collagenous extracellular matrix that fills the inside of the eye and overlies the retina.

News

Apr 4 2021 | Posted In: 20/20 Blog, Awards
Palo Alto, CA —Young Joo Sun Ph.D., postdoctoral fellow in the Mahajan Lab, received a grant from the Brightfocus Foundation to study a key protein involved in macular degeneration.
Apr 1 2021 | Posted In: 20/20 Blog
Palo Alto, CA —Through funding from The Cancer League, a local cancer charity, Prithvi Mruthyunjaya MD, MHS and  Vinit Mahajan MD, PhD
Jan 11 2021 | Posted In: 20/20 Blog
Palo Alto, CA — The Mahajan Lab is designing small-molecule injectable drugs for a number of molecular targets they identified using proteomics, the large-scale study of proteins
Jun 8 2020 | Posted In: 20/20 Blog, Press
Palo Alto, Ca — Genetic testing doesn’t always provide a diagnosis, so Vinit Mahajan M.D., Ph.D., professor of ophthalmology at Stanford University, has applied proteomics to better understand disease in his patients. 
May 1 2020 | Posted In: 20/20 Blog
 
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Publications

Personalized proteomics in proliferative vitreoretinopathy implicate hematopoietic cell recruitment and mTOR as a therapeutic target, C Roybal, Nathaniel, Velez Gabriel, Toral Marcus A., Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , American journal of ophthalmology, (2017)
Proteomic analysis of elevated intraocular pressure with retinal detachment, Velez, Gabriel, C Roybal Nathaniel, Binkley Elaine, Bassuk Alexander G., Tsang Stephen H., and Mahajan Vinit B. , American journal of ophthalmology case reports, Volume 5, p.107–110, (2017)
Therapeutic drug repositioning using personalized proteomics of liquid biopsies, Velez, Gabriel, Bassuk Alexander G., Colgan Diana, Tsang Stephen H., and Mahajan Vinit B. , JCI insight, Volume 2, (2017)
Dissection of Human Retina and RPE-Choroid for Proteomic Analysis., Cabral, Thiago, Toral Marcus A., Velez Gabriel, DiCarlo James E., Gore Anuradha M., Mahajan M, Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. , Journal of visualized experiments: JoVE, (2017)
Proteomic interactions in the mouse vitreous-retina complex., Skeie, Jessica M., and Mahajan Vinit B. , PLoS One, 2013, Volume 8, Issue 11, p.e82140, (2013)
PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders., Paemka, Lily, Mahajan Vinit B., Skeie Jessica M., Sowers Levi P., Ehaideb Salleh N., Gonzalez-Alegre Pedro, Sasaoka Toshikuni, Tao Hirotaka, Miyagi Asuka, Ueno Naoto, et al. , PLoS One, 2013, Volume 8, Issue 12, p.e80737, (2013)
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