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Proteomics Lab

Proteomics is the culmination of advances in chemistry, physics, bioinformatics, and molecular biology that allow the study of thousands of proteins simultaneously. A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest. This strategy is especially important in eye diseases where there are limited cell and animal models.

We are using proteomics to discover biomarkers, therapeutic targets, and molecular pathways involved in several eye diseases where diagnosis is difficult and current treatment is inadequate.

Projects

A multi-institution precision health consortium for collecting ophthalmic surgical samples.

We are using proteomics to study the vitreous fluid from eyes with ADNIV.

A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest.

The vitreous is an optically clear, collagenous extracellular matrix that fills the inside of the eye and overlies the retina.

News

Apr 20 2020 | Posted In: 20/20 Blog
Palo Alto, CA — Is there something to feed retinal cells that can give them the energy to withstand gene mutations that make them sick?
Mar 31 2020 | Posted In: 20/20 Blog
Palo Alto, CA — On an international Zoom conference, Gabriel Velez, an M.D., Ph.D. student in the Mahajan Lab, successfully presented his Ph.D. thesis defense seminar. 
Sep 28 2019 | Posted In: 20/20 Blog
Portland, OR — Vinit Mahajan M.D., Ph.D., Vice Chair of Research for the Stanford Ophthalmology Department, traveled to Portland, Oregon to give the keynote lecture at the 10th Annual Gained in Translation Symposium held at the OHSU Knight Cancer Research Building.  
Sep 16 2019 | Posted In: 20/20 Blog
Palo Alto, CA – The Molecular Surgery Program in Stanford’s Ophthalmology Department held the first Bay Area Genetic Retinal Disease Case Conference at the 
Sep 5 2019 | Posted In: 20/20 Blog, Press
Palo Alto, CA – The Stanford Ophthalmology Department highlighted its  clinical, surgical, and research achievements in its first annual report
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Publications

Proteomic interactions in the mouse vitreous-retina complex., Skeie, Jessica M., and Mahajan Vinit B. , PLoS One, 2013, Volume 8, Issue 11, p.e82140, (2013)
PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders., Paemka, Lily, Mahajan Vinit B., Skeie Jessica M., Sowers Levi P., Ehaideb Salleh N., Gonzalez-Alegre Pedro, Sasaoka Toshikuni, Tao Hirotaka, Miyagi Asuka, Ueno Naoto, et al. , PLoS One, 2013, Volume 8, Issue 12, p.e80737, (2013)
Evisceration of mouse vitreous and retina for proteomic analyses., Skeie, Jessica M., Tsang Stephen H., and Mahajan Vinit B. , Journal of visualized experiments : JoVE, 2011, Issue 50, (2011)
Dissection of human vitreous body elements for proteomic analysis., Skeie, Jessica M., and Mahajan Vinit B. , Journal of visualized experiments : JoVE, 2011, Issue 47, (2011)
Creatine kinase, an ATP-generating enzyme, is required for thrombin receptor signaling to the cytoskeleton., Mahajan, V B., Pai K S., Lau A, and Cunningham D D. , Proceedings of the National Academy of Sciences of the United States of America, 2000 Oct 24, Volume 97, Issue 22, p.12062-7, (2000)