Skip to content Skip to navigation

Grants to Study ADNIV

Posted In:

20/20 Blog

We received grants from the NIH and Research to Prevent Blindness to identify the gene that causes ADNIV, an inherited autoimmune condition of the eyes. 

Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is a heritable autoimmune condition. It is characterized by various stages that mimic several much more common eye diseases, including: uveitis, retinitis pigmentosa, proliferative diabetic retinopathy, and proliferative vitreoretinopathy. Together, these diseases account for a significant fraction of visual morbidity and human blindness. 

The ADNIV gene was previously mapped the genetic locus for ADNIV to chromosome 11q13.


Identification of a gene that generates the varied pathological features of these common conditions could have a significant impact on the understanding and treatment of blindness.