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Proteomic Analysis of Suspected Schwartz Syndrome

Apr 5 2017

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20/20 Blog

In this recent case, published in AJO Case Reports, we performed proteomic analysis of aqueous humor from a patient with retinal detachment and elevated retinal detachment. The patient was suspected to have Schwartz-Matsuo syndrome, but our analysis suggested a different unknown etiology. We instead identified elevated levels of HEPC and CYTC, candidate biomarkers for primary open angle glaucoma (POAG). Molecular diagnoses using proteomics can differentiate between clinical diagnoses and point to common biomarkers or disease mechanisms.