Title | Opposing T cell responses in experimental autoimmune encephalomyelitis. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Saligrama, Naresha, Zhao Fan, Sikora Michael J., Serratelli William S., Fernandes Ricardo A., Louis David M., Yao Winnie, Ji Xuhuai, Idoyaga Juliana, Mahajan Vinit B., Steinmetz Lars M., Chien Yueh-Hsiu, Hauser Stephen L., Oksenberg Jorge R., K Garcia Christopher, and Davis Mark M. |
Journal | Nature |
Date Published | 2019 Aug 07 |
ISSN | 1476-4687 |
Abstract | Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4, CD8 and γδ T cells in the blood and central nervous system, similar to gluten-challenge studies of patients with coeliac disease. We also find major expansions of CD8 T cells in patients with multiple sclerosis. In autoimmune encephalomyelitis, we find that most expanded CD4 T cells are specific for the inducing myelin peptide MOG. By contrast, surrogate peptides derived from a yeast peptide major histocompatibility complex library of some of the clonally expanded CD8 T cells inhibit disease by suppressing the proliferation of MOG-specific CD4 T cells. These results suggest that the induction of autoreactive CD4 T cells triggers an opposing mobilization of regulatory CD8 T cells. |
DOI | 10.1038/s41586-019-1467-x |
Alternate Journal | Nature |
PubMed ID | 31391585 |