Title | Optical Coherence Tomography Angiography of RPGR-Associated Retinitis Pigmentosa Suggests Foveal Avascular Zone is a Biomarker for Vision Loss. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Tang, Peter H., Jauregui Ruben, Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. |
Journal | Ophthalmic Surg Lasers Imaging Retina |
Volume | 50 |
Issue | 2 |
Pagination | e44-e48 |
Date Published | 2019 02 01 |
ISSN | 2325-8179 |
Keywords | Biomarkers, Capillaries, Choroid, Eye Proteins, Fluorescein Angiography, Fovea Centralis, Humans, Male, Middle Aged, Retinitis Pigmentosa, Tomography, Optical Coherence, Vision Disorders |
Abstract | RPGR-associated retinitis pigmentosa (RP) is a progressive disease with retina degeneration. Optical coherence tomography angiography (OCTA) is an imaging technique that provides novel insights. The authors report two affected male siblings who underwent OCTA imaging. The area of the foveal avascular zone (FAZ) was measured. Although the younger sibling exhibited more advanced clinical disease, his visual acuity was superior to his older sibling. OCTA imaging revealed a better preserved FAZ in the younger sibling as the reason for this. It also highlighted attenuation of choriocapillaris / choroid layers as biomarkers for disease severity. This provides new insights into retinal degeneration in RPGR-associated RP. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:e44-e48.]. |
DOI | 10.3928/23258160-20190129-18 |
Alternate Journal | Ophthalmic Surg Lasers Imaging Retina |
PubMed ID | 30768229 |
Grant List | R01EY024665 / NH / NIH HHS / United States R01EY025225 / NH / NIH HHS / United States R01EY024698 / NH / NIH HHS / United States R21AG050437 / NH / NIH HHS / United States P30EY026877 / NH / NIH HHS / United States |