| Title | Proteomic insight into the pathogenesis of CAPN5-vitreoretinopathy. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Velez, Gabriel, Yang Jing, Li Angela S., Tsang Stephen H., Bassuk Alexander G., and Mahajan Vinit B. |
| Journal | Sci Rep |
| Volume | 9 |
| Issue | 1 |
| Pagination | 7608 |
| Date Published | 2019 May 20 |
| ISSN | 2045-2322 |
| Abstract | CAPN5 Neovascular Inflammatory Vitreoretinopathy (CAPN5-NIV; OMIM 193235) is a poorly-understood rare, progressive inflammatory intraocular disease with limited therapeutic options. To profile disease effector proteins in CAPN5-NIV patient vitreous, liquid vitreous biopsies were collected from two groups: eyes from control subjects (n = 4) with idiopathic macular holes (IMH) and eyes from test subjects (n = 12) with different stages of CAPN5-NIV. Samples were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Protein expression changes were evaluated by principal component analysis, 1-way ANOVA (significant p-value |
| DOI | 10.1038/s41598-019-44031-7 |
| Alternate Journal | Sci Rep |
| PubMed ID | 31110225 |
| PubMed Central ID | PMC6527583 |
| Grant List | R21 AG050437 / AG / NIA NIH HHS / United States T32GM007337 / / U.S. Department of Health & Human Services | National Institutes of Health (NIH) / R01 EY018213 / EY / NEI NIH HHS / United States P30 EY026877 / EY / NEI NIH HHS / United States 2013103 / / Doris Duke Charitable Foundation (DDCF) / 5P30CA013696 / / U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) / R01 EY024665 / EY / NEI NIH HHS / United States K08 EY020530 / EY / NEI NIH HHS / United States R01 EY026682 / EY / NEI NIH HHS / United States R01 EY024698 / EY / NEI NIH HHS / United States P30 EY019007 / EY / NEI NIH HHS / United States 5P30EY019007, R01EY018213, R01EY024698, R01EY026682, R21AG050437 / / U.S. Department of Health & Human Services | National Institutes of Health (NIH) / R01 EY025225 / EY / NEI NIH HHS / United States P30 CA013696 / CA / NCI NIH HHS / United States F30EYE027986 / / U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) / K08EY020530, R01EY024665, R01EY025225, R01EY024698, R21AG050437, P30EY026877 / / U.S. Department of Health & Human Services | National Institutes of Health (NIH) / T32 GM007337 / GM / NIGMS NIH HHS / United States |
