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Viral Delivery Systems for CRISPR.

TitleViral Delivery Systems for CRISPR.
Publication TypeJournal Article
Year of Publication2019
AuthorsXu, Christine L., Ruan Merry Z. C., Mahajan Vinit B., and Tsang Stephen H.
Date Published2019 Jan 04

The frontiers of precision medicine have been revolutionized by the development of Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR)/Cas9 as an editing tool. CRISPR/Cas9 has been used to develop animal models, understand disease mechanisms, and validate treatment targets. In addition, it is regarded as an effective tool for genome surgery when combined with viral delivery vectors. In this article, we will explore the various viral mechanisms for delivering CRISPR/Cas9 into tissues and cells, as well as the benefits and drawbacks of each method. We will also review the history and recent development of CRISPR and viral vectors and discuss their applications as a powerful tool in furthering our exploration of disease mechanisms and therapies.

Alternate JournalViruses
PubMed ID30621179
PubMed Central IDPMC6356701
Grant ListP30EY019007 / / National Institutes of Health /
R01EY018213 / / National Institutes of Health /
R01EY024698 / / National Institutes of Health /
R01EY026682 / / National Institutes of Health /
R21AG050437 / / National Institutes of Health /
R24EY027285 / / National Institutes of Health /
5P30CA013696 / / National Cancer Institute /
TA-NMT-0116-0692-COLU / / Foundation Fighting Blindness / United States