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ADNIV

Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is an autoimmune disease of the eye without systemic features.

This eye-specific, inflammatory condition is characterized by the early presence of vitreous inflammation and loss of the ERG b-wave. The disease is progressive and complicated by pigmentary retinal degeneration, panuveitis, cystoid macular edema, retinal and iris neovascularization, epiretinal membrane formation, vitreous traction on the retina, vitreous hemorrhage, retinal detachment, and blindness.

The eye is an immune privileged site where the local immunological mechanisms are poorly understood. We believe understanding the cause of ADNIV will provide tremendous insight into more common eye diseases including uveitis, diabetic retinopathy, and proliferative vitreoretinopathy.

We are conducting studies into the genetics, proteomics and surgical therapy of this complex disease.

 

Please contact us for a consultation or to learn how you can support our research program.

Projects

We are using proteomics to study the vitreous fluid from eyes with ADNIV.

News

Jul 26 2016 | Posted In: 20/20 Blog
Using SAXS to probe the solution structure and conformation of CAPN5
May 18 2015 | Posted In: 20/20 Blog
CAPN5 is a gene that encodes for a calcium-activated protease. This protease plays an important role in the human body by cleaving different proteins and acting in different cell signaling cascades.
May 14 2013 | Posted In: 20/20 Blog
Our laboratory has identified the CAPN5 gene as the cause of ADNIV, an inherited autoimmune disease of the eye. This landmark discovery represents the first identified gene that causes uveitis - a blinding inflammation within the eyes. The condition is also characterized by abnormal...
Jun 16 2012 | Posted In: 20/20 Blog
ADNIV is an inherited autoimmune disease of the eye. We performed a study to determine the benefit of Retisert, an implant that delivers steroids within the eye for several years. In a study published in the journal, Archives of Ophthalmology, we found that the implant inhibited specific features...
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Publications

Inhibition of Neovascularization but Not Fibrosis With the Fluocinolone Acetonide Implant in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy., Tlucek, Paul S., Folk James C., Orien Jason A., Stone Edwin M., and Mahajan Vinit B. , Archives of ophthalmology, 2012 Jul 9, p.1-7, (2012)
Calpain-5 mutations cause autoimmune uveitis, retinal neovascularization, and photoreceptor degeneration., Mahajan, Vinit B., Skeie Jessica M., Bassuk Alexander G., Fingert John H., Braun Terry A., Daggett Heather T., Folk James C., Sheffield Val C., and Stone Edwin M. , PLoS Genet, 2012, Volume 8, Issue 10, p.e1003001, (2012)
Seroreactivity against aqueous-soluble and detergent-soluble retinal proteins in posterior uveitis., Ko, Audrey C., Brinton Jason P., Mahajan Vinit B., Zimmerman Bridget, Brinton Gregory S., Stone Edwin M., Folk James C., and Mullins Robert F. , Archives of ophthalmology, 2011 Apr, Volume 129, Issue 4, p.415-20, (2011)
T-cell infiltration in autosomal dominant neovascular inflammatory vitreoretinopathy., Mahajan, Vinit B., Vallone John G., Lin Jonathan H., Mullins Robert F., Ko Audrey C., Folk James C., and Stone Edwin M. , Molecular vision, 2010, Volume 16, p.1034-40, (2010)
Patients with an acute zonal occult outer retinopathy-like illness rapidly improve with valacyclovir treatment., Mahajan, Vinit B., and Stone Edwin M. , American journal of ophthalmology, 2010 Oct, Volume 150, Issue 4, p.511-8, (2010)
Management of sympathetic ophthalmia with the fluocinolone acetonide implant., Mahajan, Vinit B., Gehrs Karen M., Goldstein Debra A., Fischer David H., Lopez Juan S., and Folk James C. , Ophthalmology, 2009 Mar, Volume 116, Issue 3, p.552-557.e1, (2009)
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