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ADNIV

Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is an autoimmune disease of the eye without systemic features.

This eye-specific, inflammatory condition is characterized by the early presence of vitreous inflammation and loss of the ERG b-wave. The disease is progressive and complicated by pigmentary retinal degeneration, panuveitis, cystoid macular edema, retinal and iris neovascularization, epiretinal membrane formation, vitreous traction on the retina, vitreous hemorrhage, retinal detachment, and blindness.

The eye is an immune privileged site where the local immunological mechanisms are poorly understood. We believe understanding the cause of ADNIV will provide tremendous insight into more common eye diseases including uveitis, diabetic retinopathy, and proliferative vitreoretinopathy.

We are conducting studies into the genetics, proteomics and surgical therapy of this complex disease.

 

Please contact us for a consultation or to learn how you can support our research program.

Projects

We are using proteomics to study the vitreous fluid from eyes with ADNIV.

News

May 14 2013 | Posted In: 20/20 Blog
Our laboratory has identified the CAPN5 gene as the cause of ADNIV, an inherited autoimmune disease of the eye. This landmark discovery represents the first identified gene that causes uveitis - a blinding inflammation within the eyes. The condition is also characterized by abnormal...
Jun 16 2012 | Posted In: 20/20 Blog
ADNIV is an inherited autoimmune disease of the eye. We performed a study to determine the benefit of Retisert, an implant that delivers steroids within the eye for several years. In a study published in the journal, Archives of Ophthalmology, we found that the implant inhibited specific features...
| Posted In: 20/20 Blog
We received grants from the NIH and Research to Prevent Blindness to identify the gene that causes ADNIV, an inherited autoimmune condition of the eyes. 
| Posted In: 20/20 Blog
The disease stages of ADNIV phenocopy common vitreoretinal conditions. A. Linkage analysis mapped the disease-causing mutation to a 22-megabase (chr11: 91,760,018 – 69,339,635) interval on chromosome 11q13 B.

Publications

A head-tilt test for hypopyon after intravitreal triamcinolone., Mahajan, Vinit B., Folk James C., and H Boldt Culver , Retina (Philadelphia, Pa.), 2009 Apr, Volume 29, Issue 4, p.560-1, (2009)